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CBD INTERACTIONS WITH MEDICINES

The combination of CBD and certain drugs may significantly increase or decrease the efficacy of the drug. If you are using products belonging to the group of medicines below, we recommend that you discuss the use of CBD-A products with your doctor.

CBD AND EPILEPSY

In clinical trials, CBD has been shown to reduce epileptic seizures, e.g. in patients with Dravet’s syndrome. However, concomitant use of CBD and antiepileptic drugs has caused side effects in some patients. They have been common with carbamazepine (Tegretol), among others.

Other medicines that may interact:
Absenor, Deprakine, Orfiril, Frisium, Inovelo, Topimax, Zonegran, Zebinix.

CBD AND CHEMOTHERAPY

Many chemotherapy drugs are metabolized by the cytochrome p450 enzyme and may therefore have strong interactions with CBD. Caution should be exercised when using CBD with at least the following drugs:

  • Etoposide (e.g. Etoposide, Eposin)
  • Methotrexate (Metoject)
  • Paclitaxel (Paclitaxin, Paclitaxel)

Interactions are not always negative. For example, the combination of paclitaxel and CBD reduces the resulting neuropathic pain

CBD AND CARDIOVASCULAR MEDICINAL PRODUCTS

CBD can interact with many heart medications, such as statins. Statins are drugs for fat metabolism that inhibit the liver’s own cholesterol synthesis. The liver thus produces less cholesterol-containing particles in the bloodstream. There are also several beta-blockers on the interaction list.

  • Tikagrelori (Brilique)
  • Quinidine (Kiniduron)
  • Atorvastatin (Lipitor)
  • Seliprolol (Selectol)
  • Amiodarone (Cordarone)
  • Clobidogrel
  • Carvedilol
  • Nifedipine (Adalat, Procardia)
  • Valsartan (Valsartan, Diovan)
  • Pitavastatin (Livazo, Vezepra)

CBD AND MENTAL MEDICINES

Most antidepressants do not interact with CBD. Buspirone (Aksilon, Buspiron), used to treat generalized anxiety disorder, is often prescribed in addition to antidepressants. It is metabolised by the cytochrome p450 enzyme and may therefore have strong interactions with CBD. Clomipramine (Anafranil) also has similar strong interactions.

CBD AND BLOOD PRESSURE MEDICINES (calcium channel blockers)

Calcium channel blockers, blood thinners, and medications used to treat high blood pressure and arrhythmias can cause severe symptoms with CBD. CBD reduces or prevents the breakdown of drugs, for example, with warfarin (Marevan), enhancing its effect.

OTHER drugs that cause interactions are at least listed below.

  • Valsartan (Amlodipine, Valsartan)
  • Verapamil
  • Nifedipine (Adalat, Nifedipine Alternova)
  • Diltiazem (Cardizem)
  • Isradipine (Lomir)
  • Torasemidi (Torasemid, Torem)
  • Felodipine (Felodipine, Plendil)
  • Amlodipine (Ampodipine)

CBD AND SOOTHING AGENTS (benzodiazepines)

Benzodiazepines are used to treat anxiety, insomnia, nausea, depression and panic disorder.

Some benzodiazepines, such as alprazolam (Alprox, Xanor, Alprazolam) and diazepam (Diapam, Diazepam Accord), do not degrade as rapidly as CBD. As a result, their concentrations may become too high.

  • Alprazolam (Alprox, Xanor, Alprazolam, Xanax)
  • Triazolam (Triazolam, Halcion)
  • Diazepam (Diapam, Diazepam Accord)
  • Midazolam (Dormicum, Midazolam)
  • Quatsepam (Aldizem, Cardizem)
  • Triazolam (Triazolam, Halcion)

CBD AND ANTIOBIOTS

In particular, fluoroquinolones (Ciprofloxacin) may interact strongly with CBD.

  • Ciprofloxacin
  • Gemifloxacin
  • Levofloxacin
  • Moxifloxacin
  • Norfloxacin Sandoz
  • Ofloxacin (Tarivid, Exocin)
  • Rifampicin (Rimapen)

CBD AND OTHER INTERACTION MEDICINES

Cholesterol: lovastatin (Mevacor, Lovastatin)
Antimicrobials: ketoconazole (Nizoral) & itraconazole (Sporanox)
Cortisone preparation: methylprednisolone (Solu-Medrol, Solomet)
Antihistamines: fexofenadine (R Fexorin) & terfenadine (Telfast)
Erectile Dysfunction: sildenafil (Viagra)
Cholesterol lowering drug: simvastatin (Simvastatin, Zocor)
Barbiturate: Hexobarbital

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