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Endometriosis and CBD

Endometrioosi on yksi yleisimmistä naisten gynekologisista sairauksista, joka aiheuttaa voimakasta kipua ja muita oireita.

12.6.2024

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Endometriosis is one of the most common gynecological diseases in women. Endometriosis affects 10–15% of women of fertile age. In this article, we will explore the topic of endometriosis, the factors influencing its development, the endocannabinoid system behind endometriosis, and whether CBD could be helpful in managing symptoms.

What is endometriosis?


Endometriosis is a chronic disease of women in fertile age that causes pain and fertility problems. The disease is estrogen-dependent, and because of this, the symptoms usually stop at menopause. (1)

Women suffering from endometriosis have a chronic inflammatory condition in the abdominal cavity, where endometrial-like tissue (endometriosis foci) grows outside the uterus, for example in the ovaries, fallopian tubes, and on the surfaces of the uterus, intestine, and bladder. Rarely, endometriosis tissue is found outside of the pelvic area, but in some cases, endometriosis tissue can grow elsewhere in the body. Endometriosis is a chronic disease. (1)

Endometriosis usually causes severe pain, especially during menstruation. In this case, the endometriosis tissue acts like the lining of the uterus – it thickens, breaks down and bleeds during each menstrual cycle. The pain is caused by the tissue growing in places where it does not belong, and it cannot leave the body as bleeding, like menstruation. Blood leaking into the abdominal cavity irritates and inflames the adjacent tissues. (2)

Endometriosis also appears to be highly hereditary. The disease risk is 6–9 times higher if a first-degree close relative (parent, sister, child) has endometriosis. (3)

 

Symptoms and diagnosis of endometriosis


It is difficult to reliably identify the disease. According to research, a diagnostic delay of up to 6 to 9 years is typical for endometriosis, which makes it difficult to get the right treatment. A typical symptom of endometriosis is a lower abdominal pain,
which starts several days before menstruation, that does not respond to standard painkillers and forces the woman to stay home from school or work. In the beginning, the symptoms appear only during menstruation, but as the disease progresses, there are constant pains (Setälä et al. 2009). Endometriosis can have three types of foci: superficial foci, ovarian foci (endometrioma cysts) and deep foci. They cause different symptoms, and their treatment is also different depending on the case. (1)

Superficial foci are accompanied by pain and bleeding disorders. Foci are located on the peritoneum or on the surface of the tissues of the abdominal cavity. Foci can be fresh red, bright vesicular or gelatinous adherent tissue. Over time, the foci turn brown and black and become white when scarred. Superficial foci cannot be felt in a gynecological examination or seen in an echocardiogram, so a reliable diagnosis can only be reached with laparoscopy. Nerve fibers have been found in the endometrium of patients with endometriosis, which may in the future enable diagnostics from a sample taken from the endometrium. (1)

Ovarian endometriosis cysts, or endometriomas, can be found by chance in an asymptomatic woman or during an examination due to abdominal pain. Endometrioma is typically seen on echography as a round, flat-echo and cloudy change in the ovary. Endometrioma is found in 17-44% of endometriosis patients, and half of endometrioma patients have deep foci. (1)

Deep endometriosis foci are hard, scar-like, pale foci that grow more than 5 mm deep into adjacent tissue without tissue boundaries. Deep foci cause pain and other symptoms depending on their location: sacrotherine ligament colonies and rectovaginal colonies pain during intercourse and defecation; Intestinal colon pain with bowel movements and slimy or bloody stools; bladder colonies pain when urinating and hematuria (Setälä et al. 2009). (1)

Endometriosis and infertility

The main complication of endometriosis is infertility. Up to half of women with endometriosis have trouble getting pregnant.

One of the main challenges of endometriosis is that it can interfere with the normal reproductive process. Normally, an egg is released from the ovary during ovulation and then travels through the fallopian tube where it can meet a sperm cell. If endometriosis blocks the fallopian tube or damages the sperm cell or egg, it can make conception difficult. (2)

However, it is important to note that many women with mild to moderate endometriosis can still get pregnant and carry full term. This highlights individual differences in the severity of endometriosis and its effects on reproductive health. (2)

Healthcare professionals may recommend that women with endometriosis consider pregnancy relatively early, as endometriosis symptoms can worsen over time. In addition, some treatment options, such as surgery or medication, can affect fertility, so the advice given by doctors may vary according to individual needs. (2)

Research into the development of drug treatment for endometriosis is lively, but finding the exact remedy is difficult. The drug should eradicate the endometriosis foci and not just alleviate the symptoms. It is also demanding to develop a drug that would only destroy the endometriosis foci without having a harmful effect on the endometrium, the place where the embryo attaches. Various drugs have been tried in research, but unfortunately, none of them have yet proven to be effective in defeating this disease. (1)

 

Endometriosis and pain. How can CBD oil help?

One common symptom of endometriosis is lower abdominal pain that starts several days before the menstrual flow, which is not helped by the usual painkillers.

 

Endometriosis and pain

 

Mechanisms related to endometriosis pain are at both central and peripheral nervous levels. In endometriosis, each patient’s pain experience is different, and one pain mechanism can dominate over the others. This may be due to differences in pathogenesis or disease entities, meaning symptoms may only respond to certain treatments and at a certain stage of the patient’s menstrual cycle.

Pain mechanisms associated with endometriosis are complex and interrelated and can be divided into three main categories of pain: nociceptive, inflammatory, and neuropathic pain. (5)

 

Nociceptive pain:


This type of pain is caused by the activation of nociceptors. They are sensory receptors of the peripheral nervous system capable of converting noxious stimuli (such as mechanical, chemical and thermal) into energy, usually at a high threshold.(5)


Inflammatory pain:


Inflammatory pain is part of the nociceptive pain complex. Inflammatory mediators interact with neurons to produce hypersensitivity and modify pain perception. Inflammation is involved in pain mechanisms because inflammatory cytokines, tumor necrosis factor-α and interleukin-1β regulate nerve growth factor. Endometriosis can be considered a chronic inflammatory disease. (5)

 

Neuropathic pain:

Neuropathic pain is associated with nerve cell self-damage as a result of infection or injury in the area, resulting in pain signals being sent to the central nervous system regardless of noxious stimuli. Neuropathic pain is often described as “shooting” pain because it travels along the nerves in an abnormal way, causing abnormal pain.

In endometriosis, psychological factors can also influence the nature of the disease. Since the disease especially affects women of fertile age, it often results in fertility problems or dyspareunia (pain during intercourse). Both problems can understandably cause anxiety and can even increase the experience of pain.

These symptoms can also affect self-esteem and relationships, further exacerbating the pain experienced by the patient. (5)

 

The endocannabinoid system and cannabinoid receptors

 

The endocannabinoid system (ECS) is a central biological system involved in the regulation of many physiological processes. The ECS consists of cannabinoid receptors (CB1 and CB2), the TRPV1 ion channel, endocannabinoids (such as anandamide and 2-AG), and enzymes responsible for the synthesis and degradation of these molecules. The ECS system regulates e.g. pain, inflammation, mood, and immune response, and plays an important role in both health maintenance and disease pathogenesis. Understanding the ECS opens up new possibilities in the treatment of various diseases, such as endometriosis. (6)

CB1 cannabinoid receptors belonging to the endocannabinoid system are found mainly in the brain and central nervous system, but also in some peripheral tissues. They influence neurotransmission and many physiological processes, such as pain perception, mood and appetite. CB2 receptors are mainly found in the immune system and peripheral nervous system. They are related to the immune response and regulation of inflammation. (5)

The endogenous ligands (endocannabinoids) are Anandamide (AEA) and 2-arachidonylglycerol (2-AG). AEA is the first discovered endocannabinoid that binds to CB1 receptors and affects e.g. mood and pain. 2-AG, on the other hand, is more abundant in the body and binds to both CB1 and CB2 receptors, participating in many physiological functions. (5)

We tell you more about the endocannabinoid system and its function in the article The purpose of the endocannabinoid system

 

Endometriosis and endocannabinoids

 

Studies have shown that the ECS is primarily involved in pain regulation and prevention of inflammation. Endocannabinoids or exogenous cannabinoids have been shown to activate CB1 and CB2 receptors, which are critical components of the G-protein coupled system, thereby suppressing nociceptive processing and causing analgesia (pain relief). (6)

In addition, the ECS is hypothesized to play a central role in the pathology of endometriosis, and some researchers refer to the disease as “endocannabinoid deficiency.” Strong correlations have been observed between circulating plasma endocannabinoid levels and the severity of endometriosis, with lower endocannabinoid levels being associated with increased pain. However, other studies have shown that endometriosis and ECS may have complex connections, where the onset of the former initiates a feedback loop in the latter. This indicates that the role of the ECS in endometriosis may extend beyond the suppression of inflammation and pain, and warrants further investigation into the mechanisms underlying these interactions.(6)

The study focused on the effects of endocannabinoids on disease outcomes and the connections between ECS, gut microbiota/microbiota/microbiome and endometriosis. Although publication screening methods are not reported here, the reference list suggests that more than 140 scientific articles were examined during the synthesis of this work. (6)

In another study, researchers compared plasma levels of endocannabinoid ligands [AEA, 2-AG, N-oleoylethanolamine (OEA) and N-palmitoylethanolamine (PEA); OEA and PEA are two AEA compounds and share the same biosynthetic and catabolic pathways with AEA].

They are often associated with endocannabinoids in tissues and mRNA expression of some major receptors (CB1, CB2, TRPV1) in endometrial cells in women with or without endometriosis. They then analyzed the relationship between endometriosis-related pain levels and symptoms.

They found a significant increase in plasmatic endocannabinoid ligand with reduced local CB1 expression in women with endometriosis compared to those without endometriosis. This result suggests negative feedback regulation, which may impair the ability of these mediators to control pain in endometriosis patients. Since the most common symptoms of endometriosis-related pain are CPP, dysmenorrhea, and dyspareunia, the authors measured endocannabinoid ligands in women who experienced any of these symptoms. They also found elevated AEA levels in women with moderate to severe dysmenorrhea and elevated PEA levels in women with moderate to severe dyspareunia. (5)

CBD has also been studied with the help of rats that had been implanted with endometriosis foci. The rats were divided into four different groups:

  • 1. Leuprolide diacetate group that received CBD at a dose of 1 mg/kg.
  • 2. CBD 5 mg/kg group.
  • 3. Saline group.
  • 4. CBD 20 mg/kg group.

Each group was given daily injections for 7 days, after which the state of health was examined in various aspects. In the CBD5 group, e.g. significant decreases in the surface of the endometriotic implant-area , serum oxidation state and oxidative stress index compared to the saline group .

The conclusion of the study was that due to the anti-inflammatory, anti-oxidative and anti-angiogenic effects of CBD, it may be a promising therapeutic agent in the treatment of endometriosis. This suggests that CBD may have the potential to relieve pain and other symptoms associated with endometriosis. (4)

Endometriosis and cannabinoid deficiency

 

As shown in previous studies, the treatment of endometriosis involves the endocannabinoid system, which interacts with certain pain-generating mechanisms such as inflammation, cell proliferation, and cell survival. These mechanisms play a central role in the pain associated with endometriosis, as well as in the initiation, maintenance and recurrence of the disease.

Cannabidiol ( CBD ) and tetrahydrocannabinol ( THC), the two main active ingredients derived from hemp have been studied in many medical studies. Research suggests that cannabinoids can have a positive effect on the body’s endocannabinoid system (ECS). The ECS consists of various receptors located throughout the body, including the reproductive organs. Cannabinoids such as CBD and THC interact with these receptors and can produce a variety of effects. (5,6)

Some of the studies we reviewed described endometriosis as an “ endocannabinoid deficiency”, which partially explains its effect on pain. In fact, women with endometriosis have lower levels of CB1 receptors in their endometrial tissue. Weakened function of the ECS is believed to lead to the growth of endometriosis tissue and a stronger pain experience. Therefore, the endocannabinoid system may be important in detecting endometriosis-related pain. (5)

Cannabidiol (CBD) in particular has well-documented pain-relieving, anti-inflammatory and anti-depressant properties. In addition, it can help reduce anxiety and nausea. The use of cannabinoids in other chronic pain conditions has also led to people reducing the use of other drugs, especially opioids, by replacing them with cannabinoids. This has partly led to interest in the medicinal use of cannabinoids in chronic pain and other diseases.

Because of their relative affordability and easy availability, the use of cannabinoids has become a popular self-treatment for endometriosis pain. (6)

However, it is important to note that the medicinal use of cannabinoids and their effects should be further studied. In addition, it is important to take into account possible side effects and individual differences in drug use. (5)

 

Other treatments and prevention


Since a large part of the body’s immune system originates from the digestive tract, a healthy digestive system is a prerequisite for an effective immune system. A healthy gut and digestive system promote the production of good bacteria, enzymes and vitamins that help fight disease. A strong and vigorous immune system helps fight the original causes of endometriosis. The body is sensitive to food allergies, including too much sugar or caffeine in the diet. Sometimes these sensitivities have certain signs and symptoms, but if not detected early, they lead to nutritional deficiencies and poor health. However, the body gives indications and requires improvements to the diet.

Inflammation is thought to be the process behind endometriosis and a key factor in its symptoms, such as chronic pain. Some research suggests that an optimal balance of omega-3 fatty acids can lead to a healthy, non-inflammatory balance in the body. Omega-3 fatty acids can be obtained, for example, from fatty fish, hemp seeds, hemp seed oil, flax seeds, flax seed oil, and walnuts, and by eating plenty of fruits and vegetables. Omega-3 fatty acids are often recommended in the treatment of endometriosis because they are believed to reduce inflammation and help with chronic pain symptoms. Eating processed food and trans fats is not recommended, because they increase the inflammatory state of the body. Regular exercise can help maintain a healthy weight and reduce inflammation in the body. It can also help relieve stress, which can make endometriosis symptoms worse. (7,15)

Herbs in the treatment of endometriosis. Dandelion.

Dandelion is an effective medicinal herb in the treatment of endometriosis.

 

Herbs in the treatment of endometriosis

According to the research results, herbs and phytoconstituents of herbal plants played a significant role in the treatment of endometriosis. Herbs that affect the pelvis and abdomen can be used as pain relievers individually or in combination. (8)

Ginseng

The active ingredient of the ginseng plant, ginsenoside Rg3, appears to be a promising treatment option for endometriosis. Ginsenoside Rg3 is derived from plants of the Panax genus and has many beneficial properties such as antioxidant and anti-inflammatory effects.

Studies have shown that ginsenoside Rg3 can suppress endometriosis by regulating cell death and angiogenesis processes in the endometrium. This can help prevent endometriosis tissue from growing and spreading.

Clinical studies have shown that ginsenoside Rg3 can be effective in the treatment of endometriosis and achieve high efficacy with minimal side effects when administered in combination with other drugs such as gestrinone.(9)

Ashwagandha

The herb ashwagandha (Withania somnifera) has a clinically significant ability to reduce stress. According to the study, women with advanced endometriosis had significantly higher cortisol levels. Cortisol is one of the most prominent stress hormones in the body, and high levels of it can be associated with various stressful situations in the body, including advanced endometriosis.

For this reason, ashwagandha can be considered as part of a comprehensive treatment plan for women with endometriosis. (8,15)

Garden Angelica

Garden angelica (Angelica archangelica) is a plant that has traditionally been used as a medicine in many cultures to treat various health problems. Its root has been particularly used in traditional medicine and has been studied in the treatment of many different ailments, including indigestion and pain conditions.

There are indications in some studies that the root of the Garden angelica or its extracts could be used to relieve the symptoms of endometriosis, especially in pain management. However, it is important to note that while there are some studies that suggest that Garden angelica may have certain health benefits, more research is needed to confirm its effectiveness and safety in the treatment of endometriosis.

Chewing the root of Garden angelica relieves the pain of endometriosis. (8,10)

 

Calendula

Calendula (Calendula officinalis) has really versatile health effects, such as anti-bleeding, anti-inflammatory and lymphatic properties. Calendula contains anti-inflammatory compounds such as flavonoids and carotenoids. These substances can help reduce inflammation in the body and thus relieve pain and discomfort. Calendula can also help stop minor bleeding, such as bleeding from wounds or minor cuts, thanks in part to its anti-inflammatory properties.

Calendula is believed to have a positive effect on the flow of lymph fluid. The lymphatic system is an important part of the body’s defense mechanism, and its proper functioning is essential to the health of the immune system. (8)

 

Echinacea

Echinacea is an herb that has traditionally been used to support the immune system and fight various infections. Studies have found that red bean can have many health benefits, such as reducing inflammation, stimulating the immune system, and increasing the production of various immune cells and molecules such as phagocytes, cytokines, and immunoglobulins.

Phagocytes are immune system cells that absorb and digest foreign microbes in the body. Cytokines are proteins that act as messengers between immune system cells and can regulate inflammatory responses. Immunoglobulins, on the other hand, are antibodies that are important in the body’s defense against infections. (8)

St. John’s wort

St. John’s wort (Hypericum perforatum) is an herb that has traditionally been used to treat depression and anxiety. It has also been studied for its effect on other health problems, such as endometriosis.

St. John’s wort can affect estrogen levels and estrogen metabolism in the body. In particular, it is known to increase the activity of the cytochrome P450 3A4 enzyme. This enzyme is an important part of the liver’s metabolic process, which breaks down various substances, including drugs and steroids.

Increased cytochrome P450 3A4 activity can accelerate the breakdown of estrogens such as ethinylestradiol in the body. This can result in lower estrogen levels, which can be helpful in situations where elevated estrogen levels are a problem, such as endometriosis.

However, it is important to note that St. John’s wort can also affect the metabolism of other drugs, which can cause harmful interactions. That’s why it’s extremely important to talk to your doctor before using St. John’s wort, especially if you’re taking other medications. (8)

Lady’s Mantle

Lady’s mantle (Alchemilla vulgaris) is an herb that has traditionally been used to treat women’s health problems, especially menstrual disorders such as menorrhagia. Menorrhagia refers to very heavy periods that can be bothersome and cause significant bleeding.

Lady’s mantle has been found to have progesterogenic properties, which means it can help balance hormone levels in the body and thus alleviate menstrual irregularities. In addition, the plant contains tannins, which can help constrict the blood vessels in the uterus and prevent excessive bleeding.

According to a Romanian study, a treatment based on Lady’s mantle extract had anti-bleeding and prophylactic effects in young girls with menorrhagia. This suggests that Lady’s mantle may be a useful alternative treatment for managing menstrual disorders. (8)

Cat’s Claw

Cat’s Claw (Uncaria tomentosa) is a climbing plant that has traditionally been used in the Amazon rainforest to treat many health problems. It is especially known for its antioxidant and anti-inflammatory properties.

Cat’s claw contains bioactive compounds such as alkaloids and polyphenols that are responsible for its health benefits. These compounds have been studied for their ability to fight inflammation and reduce oxidative stress in the body. Additionally, cat’s claw can help stimulate the immune system and promote overall health. (8)

Chastity tree

Chastity tree or chaste tree (Vitex agnus-castus) is a plant that has traditionally been used in the treatment of women’s health problems, such as menstrual irregularities and premenstrual syndrome (PMS). Known for its antioxidant and anti-inflammatory properties, it has been found to help manage many women’s health issues.

Although chaste tree is not usually directly associated with the treatment of endometriosis, in some cases it may provide relief from menstrual irregularities and associated symptoms such as pain and inflammation.

There is little scientific evidence on the use of chastity tree and its effectiveness in the treatment of endometriosis. In addition, each individual’s situation and reaction to treatment may vary. (8)

Chamomile

Chamomile (Chamomilla recutita or Matricaria chamomilla) has traditionally been used in the treatment of various health conditions, including indigestion, insomnia and inflammation. There is some research that suggests that chamomile may be helpful in relieving the symptoms of premenstrual syndrome (PMS). In addition, some natural healers have suggested that drinking chamomile tea could also help with endometriosis symptoms.

A 2018 study showed that a compound called chrysin, found in chamomile, can suppress the growth of endometrial cells. This may be relevant in the treatment of endometriosis, as endometriosis is characterized by the growth of the endometrium outside the uterus, which can cause pain and other symptoms. (8,15)

Peppermint

Peppermint (Mentha × piperita) has antioxidant properties that can help fight cell damage and inflammation in the body.

Studies have shown that antioxidants may be helpful in treating endometriosis, particularly by reducing associated pelvic pain. In addition, the use of peppermint has been found to have positive effects in relieving menstrual pain. (8,15)

Lavender

Lavender (Lavandula angustifolia) is an herb that has traditionally been used as a relaxing and calming agent in the treatment of many health problems. Lavender oil used in an aromatherapy massage can provide relief from menstrual cramps.

Research suggests that using lavender oil in a massage may be helpful in reducing pain experienced during menstruation, including severe menstrual pain that can be associated with endometriosis. Lavender oil may have relaxing and pain-relieving properties that can help relieve menstrual discomfort. (8,15)

Dandelion

Dandelion (Taraxacum officinale) may affect endometriosis in several ways. Dandelion may reduce estrogen levels in the body, as the growth of endometriosis tissue is dependent on estrogen levels. In addition, the root can regulate progesterone receptors and follicle-stimulating receptors in addition to estrogen receptors. This may help balance the hormone balance and reduce the symptoms caused by endometriosis.

The root also has anti-inflammatory properties, which can help reduce the inflammation caused by endometriosis and thus relieve symptoms such as pain and discomfort. (11)

 

Ginger

Ginger (Zingiber officinale) is widely used in traditional medicine for its anti-inflammatory and antispasmodic properties. It has been studied in the treatment of various inflammatory diseases, such as dysmenorrhea, or menstrual pain, which can be associated with endometriosis.

The anti-inflammatory properties of ginger can help reduce inflammation that can cause pain. In addition, its antispasmodic effects can help relax the muscles of the uterus and reduce the spasms that can cause pain during menstruation.

Studies from 2014 and 2016 have shown that ginger can have a significant effect in relieving menstrual pain. Although there may be less direct evidence for ginger’s effect on endometriosis pain, it is possible that its anti-inflammatory and antispasmodic effects may provide relief for endometriosis pain as well.

Ginger can be used in a variety of ways, including as a tincture, poultice, or infusion in baths, and many people have found it helpful in treating menstrual cramps. (8,15)

Curcumin

Curcumin (Curcuma longa), the active compound in turmeric, is known for its many health benefits, including its antioxidant, anti-inflammatory and anti-proliferative properties. These properties may offer potential relief from endometriosis symptoms.

Studies have shown that curcumin can reduce the number of microvessels and the expression of VEGF protein in the ectopic endometrium, which can help prevent the growth and spread of endometriosis tissue.

In addition, curcumin may have an effect on estrogen production, which may be relevant in the treatment of endometriosis, as estrogen may promote the growth of endometriosis tissue. Curcumin’s anti-inflammatory effects may also help reduce the inflammation and pain caused by endometriosis. (8,15)

However, it is important to note that while the above mentioned herbs may provide the aforementioned health benefits, they are not a substitute for medical treatment. The use of herbs may have an effect together with medication. If you use regular medication, we recommend talking to your doctor before trying the above herbs.

Not all herbs may work for everyone, and individual reactions may vary. In addition, the use of herbs does not necessarily have the same effect on everyone, and their effectiveness may vary according to individual needs.

 

Other treatments and castor oil

Resveratrol is a polyphenol that occurs naturally in many plants such as red wine, berries and peanuts. It is known for its anti-inflammatory properties, which can provide many health benefits.

Resveratrol has an anti-inflammatory effect in several ways. One of its most important mechanisms is its ability to inhibit the release of certain cytokines, which are important mediators of inflammation, as their overactivity can lead to chronic inflammation in the body. By preventing the release of these cytokines, resveratrol can help reduce inflammation.

In addition, resveratrol can reduce the production of reactive oxygen species in monocytes. Reactive oxygen species are byproducts of cell metabolism that can cause cell damage and inflammation. By reducing their production, resveratrol can help protect cells from inflammatory damage.

Resveratrol has attracted interest as a potential therapeutic agent in a variety of diseases, including cardiovascular disease, inflammatory diseases, and even cancer. (12)

Palmitoylethanolamide (PEA) is a fatty acid amide that acts as an endocannabinoid-like compound. It occurs naturally in the body and has many documented health benefits, including anti-inflammatory and pain-relieving effects.

PEA is known to reduce chronic inflammation and help control pain and inflammation. Its anti-inflammatory properties are based in part on its ability to interact with the endocannabinoid system, which regulates inflammatory responses and the perception of pain in the body.

In addition, PEA has antibiotic, immunomodulatory and neuroprotective effects, which makes it an interesting compound in the treatment of many different health problems.

One of the advantages of PEA is that it is well tolerated and generally has no adverse side effects in animals or humans. This makes it an attractive option for many people looking for a natural way to relieve chronic pain and inflammation. (12)

Castor oil has been used for thousands of years for its medicinal properties. The effects of castor oil are based on ricinoleic acid and hydroxylated fatty acid, which is released from castor oil by intestinal lipases. Despite the widespread use of castor oil in traditional and folk medicine, the molecular mechanism of ricinoleic acid is still not well understood. According to research, ricinoleic acid activates the EP3 prostanoid receptor, which transmits its health-promoting effects to the body.

Castor oil has anti-inflammatory and analgesic properties that can help reduce cramps, pelvic discomfort, and lower back pain.

It is also rich in ricinoleic acid, a fatty acid that can penetrate deep into the skin and help soften masses and blockages and increase circulation. (13)

Endometriosis can also be treated with external castor oil packs. Using these offers the opportunity to relax by calming the central nervous system, which also balances hormones and relieves stress, depression and anxiety. (14)

 

Summary

Endometriosis is one of the most common gynecological diseases in women , which affects approximately 10–15 % of women in fertile age.

TA healthy lifestyle can help manage the symptoms of endometriosis. Versatile activities, exercise, a healthy diet, vitamins, exercise and adequate rest can all contribute to overall well-being. In addition, activation of the endocannabinoid system can provide additional help in managing symptoms, as the system is supposed to play a central role in the treatment of endometriosis , and some researchers call the disease an “endocannabinoid deficiency state”.

Magnesium, acupuncture, and B vitamins, especially vitamin B6, have also been suggested to have positive effects in managing endometriosis. However, there are many individual factors involved in the use of these nutrients and treatments, and their effectiveness may vary from person to person.

Taking care of yourself, such as relaxing your mind and body during stressful times, is important when living with endometriosis. Relaxation techniques such as meditation can help manage stress and ease pain. According to research results, many herbs also play a significant role in the treatment of endometriosis. Herbs that affect the pelvis and abdomen can be used as pain relievers individually or mixed together.

 

SOURCES

  1. P. Härkki, Duodecim, 2011. Current treatment of endometriosis. https://www.duodecimlehti.fi/duo99751. Referenced 26/02/2024
  2. Sandhya Pruthi, MD2023. What is endometriosis? https://www.mayoclinic.org/diseases-conditions/endometriosis/symptoms-causes/syc-20354656. Referred on 27/02/2024
  3. What is endometriosis? Korento.fi. www.korento.fi/tietoa/endometriosis. Referred 2/22/24
  4. S. Berkem Okten, 2023 Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model. https://www.sciencedirect.com/science/article/abs/pii/S1472648323000561. Referred on 22/02/2024
  5. J. Bouaziz et al. 2017. Cannabis Cannabinoid Res. Clinical Significance of Endocannabinoids in Endometriosis Pain Management. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436335/. Referenced 2/28/2024
  6. H.Souza et al.2023. Cannabis shows promise in easing endometriosis pain, new research suggests. https://www.news-medical.net/news/20231114/Cannabis-shows-promise-in-easing-endometriosis-pain-new-research-suggests.aspx. Referenced 26/02/2024
  7. J. Hailes Foundation, 2019. Endometriosis and natural therapies. https://www.jeanhailes.org.au/health-a-z/endometriosis/endometriosis-natural-therapies. Referred on 22/02/2024
  8. C. Deliv, 2019. Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637095/. Referenced 2/24/2024
  9. C. Silva, 2019. Active Component of Ginseng Seen to Suppress Endometriosis in Study of Patient Cells. https://endometriosisnews.com/2019/10/31/ginseng-active-component-suppress-endometriosis-in-patient-cell-study/. Referenced 2/24/2024
  10. H. Kress. 2011. Chewing the root relieves the pain of endometriosis. Henriette’s Herbal Homepage. https://www.henriettes-herb.com/blog/hotw-angelica.html. (Angelica archangelica)
  11. S. Piippo. 2018 Medicinal plants of Finnish nature (book). Dandelion. p.181
  12. P. Clayton et al. 2021. International Journal of Molecular Sciences. Palmitoylethanolamide: A Natural Compound for Health Management. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157570/. Referenced 2/24/2024
  13. S. Tunaru et al. 21/05/2012. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384204/. Referenced 2/28/2024
  14. E. Cronkleton, 13.10.23. Can You Use Castor Oil Packs for Endometriosis Symptoms. https://www.healthline.com/health/castor-oil-packs-for-endometriosis. Referenced 26/02/2024
  15. K. Isometsä, 2022. Which herbs help with endometriosis symptoms? https://terveytta.net/mitka-yrtit-auttavat-endometrioosin-oireissa. Referenced 2/24/2024
  16. What is endometriosis? https://korento.fi/tietoa/endometrioosi/. Referenced 1/3/2024



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Black cumin oil

Black cumin oil

Black cumin oil is obtained by pressing the seeds of the Nigella Sativa plant. The plant has been traditionally used as a medicine and spice for thousands of years. The earliest references date back to ancient Egypt. Black cumin seeds have been found in the tomb of...

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CBD creams now permanently more affordable

CBD creams now permanently more affordable

The prices of popular CBD cosmetic creams were significantly reduced. The manufacturing prices of the products fell, so the online store prices were also permanently updated to be more affordable. You can read more detailed information about the product's features by...

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