CBD, Immunity and Autoimmune Diseases

CBD, Immunity and Autoimmune Diseases

Autoimmune diseases are increasing rapidly. There are more than 100 different autoimmune diseases and it is estimated that around five percent of the population has an autoimmune disease. Autoimmune diseases are often challenging to treat, and there is not always an effective medicine for them. In this article, we look at immunity, autoimmune diseases and whether CBD has an effect on them.


Natural immunity


Immunity is a natural synergistic ensemble of the body’s defense systems, which includes all defense and protection systems that protect us from various physical external harms, such as bacteria, viruses, parasites and harmful microbes. The most important function of the immune systems is to divide the elements moving in the body into own and foreign, threats and safe.

Immunity builds up strong already during childhood forest trips. It is important to be exposed to microbes as widely as possible from early childhood, because the phenomenon called the hygiene hypothesis can already be seen. The hygiene hypothesis means that people who grew up in too clean an environment are more prone to allergies and e.g. for asthma because they have not had enough contact with different microbes and pathogens so that the body could have created a strong immunity when encountering them (1).

Immune system dysfunction


The body has two ways to fight pathogens; lymphocytes, i.e. lymphocytes, circulate in the blood destroying pathogens, or cells specialized in fighting diseases produce antibodies circulating in the blood, which can neutralize pathogens by their action. Sometimes the functioning of the immune system can be disrupted. It can be mild, in which case the systems only work overactively, and as a result, e.g. asthma, allergies or skin symptoms such as atopic dermatitis. A more serious disorder in the immune system causes autoimmune diseases. (1,2)


What is an autoimmune disease?


The background of an autoimmune disease is always a malfunction of the immune system that causes inflammation in the body. For some reason, the body’s defense mechanisms do not work as they should, and they no longer separate pathogens from the body’s own cells and tissues. Defense and protection systems turn against the body itself as an inflammatory reaction. (2)

Autoimmune disease is caused by low immunity, an external pathogen, and in some cases also a hereditary factor. (1) According to the current understanding, there is no preventive treatment, but immunity can be strengthened by many means.

Joint pain is a common symptom of autoimmune disease.

Rheumatoid arthritis is a very common autoimmune disease in which the structures of the small joints have a continuous tissue-damaging inflammatory state. Other common autoimmune diseases include celiac disease, various allergies, asthma, psoriasis and thyroid disorders.

There is a long list of autoimmune diseases


More than 100 different forms of autoimmune diseases are known. All of them have in common the difficulty of being medicated and a large number of questions. Although there is a theory about how autoimmune diseases break out, their origin is still largely a mystery. The most common autoimmune diseases are thyroid dysfunction and rheumatoid arthritis. Asthma, allergies, celiac disease, chronic fatigue syndrome and psoriasis are also diseases classified as autoimmune. Rarer autoimmune diseases include e.g. adrenal gland dysfunction and myasthenia gravis causing muscle weakness. MS disease is also classified as an autoimmune disease and due to CBD oil’s effect on it, can read here.


Autoimmune rashes


Eczema and skin diseases that can be classified as autoimmune diseases include e.g. red lichen, vitiligo affecting the skin’s pigmentation and erythema multiforme with many symptoms. Many autoimmune diseases have several different symptoms. Rashes and skin symptoms are not associated with all diseases, but in some they are a significant factor. Psoriasis is a well-known skin-related disease based on immune defense. The symptoms of autoimmune diseases that appear as a rash may be relieved by CBD oil, and from that possible effect, you can read more here.


Endocannabinoid system behind immune defense


The endocannabinoid system is also part of the function of the immune response. It has an effect on the background of all body systems and, balancing, regulates the body’s immune defenses. The endocannabinoid system has been found to be present in some way in all cells of the body and their functions, including cells of the immune system. It also plays an important role in communication between these cells. (3,4,5)

Endocannabinoids activate the immune response


With endocannabinoids AEA (anandamide) and 2-AG (2-arachidonoylglycerol) have many important functions in the functioning of the immune system and can be considered effective immunomodulators. They e.g. both activate and inhibit immune system function and inhibit cytokines that cause inflammation. (5) Cells of the immune system have been found to have cannabinoid transport and degradation mechanisms and express both cannabinoid receptors (CB1 and CB2).

Red blood cells and chronic inflammation due to autoimmune disease.

Autoimmune disease involves inflammation in the body, which CBD can help with. CBD has an anti-inflammatory effect.


The CB2 receptor prevents inflammation


The primary location of the CB2 receptor in the body is the organs and tissues responsible for immunity. CB2 receptors are found in the cells of the immune systems approx. 100 times more than the CB1 receptor and that makes the endocannabinoid system a significant research target in the treatment of autoimmune diseases (5). The CB2 receptor is activated in the immune system and it has been noticed e.g. as an anti-inflammatory in various diseases such as inflammatory pain and liver infections. When activated, CB2 receptors also regulate the migration of immune cells in the body and their number increases during inflammatory pain (6)


The well-being of the immune system


Strong immunity is a basic pillar of health. The good immunity acquired as a child is the basis throughout life, but it can also be strengthened in adulthood. Immunity can be weakened, for example, due to stress, antibiotic courses or chronic illness. Also smoking, heavy alcohol use, lack of vitamins, etc. decrease the body’s ability to resist external pathogens. It is known that in addition to a healthy lifestyle, the immune response is also positively affected by the well-being of the mind.

Twice Nobel laureate Dr. Linus Pauling has said:

“You can trace every sickness, every disease, and every ailment to a mineral deficiency.”

A lack of micronutrients can weaken the normal function and effect of enzymes and vitamins in the body. A lack of vitamins can be avoided with well-absorbed supplements such as capsules containing humic and fulvic acid, which promote the normal functioning of the immune system (vitamin C, iron, copper and selenium). Humic substances enhance the absorption of minerals and thus help increase energy production and support immunity. You can order humus capsules from Hamppumaa’s online store.


CBD oil for autoimmune diseases


People with autoimmune diseases often use immunosuppressive treatments, i.e. treatments that lower immunity, because the immune system is overactive and needs to be calmed down.

CBD has been found in studies to be both immunosuppressive and anti-inflammatory. These properties are significant when considering the treatment of autoimmune diseases, as CBD can both slow down and stop an overactive immune system.

All autoimmune diseases differ from each other, which means that the guilty cells are also individual in each form of the disease. The contribution of endocannabinoids and the endocannabinoid system to immunity and autoimmune diseases is so significant that one could develop their own cannabinoid preparations for the diseases according to the purpose. While waiting for them, CBD oil might be of great help.


CBD oil dropper bottle and hemp plant in the background.

CBD has significant properties for the treatment of autoimmune diseases. CBD can slow down an overactive immune system.



CBG (cannabigerol)

CBG or cannabigerol is a phytocannabinoid that has an anti-inflammatory or inflammation-reducing effect. It affects the function of immune cells and their neurotransmitters. CBG also acts as an anandamide reuptake inhibitor. (6).


Effect of terpenes

Terpenes are one of the less talked compounds in hemp. Terpenes are part of the therapeutic effect of hemp and they are involved in full-spectrum CBD oil. Carophyllenes have been found e.g. antimicrobial, antioxidant and anti-inflammatory. 46D-limonene can be anti-inflammatory and Gamma-terpinene has an effect on cytokine activity. (6)



Autoimmune diseases are common, but despite all the research, still largely unknown. It is very possible that in the future, effective specific drugs from cannabinoids will be developed for autoimmune diseases.




  1. Anttila V-J.. 2021. Duodecim. Elimistön Vastustuskyky. https://www.terveyskirjasto.fi/dlk01150. Referred to 5.6.2022.
  2. Mustajoki P.. 2018. Duodecim. Autoimmuunisairaudet. https://www.terveyskirjasto.fi/dlk00010. Referred to 5.6.2022
  3. Nichols J. ja Kaplan B.. Immune responses regulated by cannabidiol. https://pubmed.ncbi.nlm.nih.gov/?term=Kaplan%20BL%5BAuthor%5D. Referred to 5.6.2022.
  4. Almogi-Hazan O., Reuven O.. Cannabis, the endocannabinoidsystem and immunity – the journey from the Bedside to the bench and back. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352399/. Referred to 5.6.2022.
  5. Pandey R., Mousawy K., Nagarkatti M., Nagarkatti P.. 2009. Endocannabinoids and immune regulation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044336/. Referred to 5.6.2022.
  6. Giorgi V., Marotto D., Batticciotto A., Atzeni F., Bongiovanni S., Sarzi-Puttini P.. 2021. Cannabis and autoimmunity : Possible mechanisms of action. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313508/. Referred to 5.6.2022
CBD Oil Dosing – The Complete Guide to Dosing

CBD Oil Dosing – The Complete Guide to Dosing

In this guide, we focus on the use and dosing of CBD oil. Proper dosing of CBD oil is important to get the most out of it without using it too much or too little. Ideally, it should not be necessary to use large amounts of CBD oil on a regular basis and it is especially important to start with a low dosage at first. Users unfamiliar with CBD may experience drowsiness and dry mouth as a side effect.

Excessive use in huge amounts can be useless and become costly when the necessary effects can be achieved even in smaller amounts. Of course, there are difficult cases where the amounts are large in order to obtain the necessary benefits. According to studies, the half-life of CBD in the body varies between 2 and 5 days, depending on e.g. user weight, metabolism, and amount of exercise.

Although studies suggest that CBD and other cannabinoids help to balance the body’s endocannabinoid system in many ways, it is still unclear how certain effects are repeatedly obtained in different people (1). Further randomized and controlled studies are needed to provide definitive clinical guidance.

So do not take the things written on the page as literal instructions, but rather as guidelines from which to start seeking the right dosage for yourself. The most important thing is to use researched high quality CBD oil and observe how your own body reacts to CBD oil.


Briefly about CBD oil and the contents of the dosage article


CBD oil popularity has grown exponentially in recent years and more and more people are taking CBD oil to support their well-being. In 2019, up to 14% of the U.S. population used it CBDand every third there has at least tried the CBD (The Gallup Poll Social Series GPSS 2019). A huge number of people use CBD and other cannabinoids to balance the well-being of their bodies and minds.

There are many different types of CBD oils and products. There are big differences in quality and concentration, and unfortunately there are still products on the market that do not even contain CBD or other cannabinoids, but only contain hemp seed oil.

In addition to the quality and concentration of the product, the effects and dosage of the CBD oil you choose will depend on whether the product is a CBD isolate or a full-spectrum or broad-spectrum CBD oil. For studies show that CBD acts in combination with cannabinoids, terpenes and flavones, which occur naturally in hemp. (2)

Full Spectrum CBD oil refers to a product that contains all (or a large amount) of various cannabis plant compounds such as cannabinoids, flavonoids, terpenes, which have been shown to have more diverse effects. A CBD isolate is a product that contains only CBD. THC has been removed from Broad Spectrum CBD oil. For safety reasons, CBD oils made from industrial hemp do not need to be stripped of THC, as concentrations below 0.2% do not have any intoxicating effects, but its presence makes the product more effective.

In this article, we’ll cover everything essential you should know about CBD oil and how to use it.

  • How much CBD oil needs to be used at one time?
  • How do I know what the appropriate dose is?
  • How many drops of CBD oil should you take in proportion to your weight?
  • What factors affect the amount of dosage?
  • Do you get CBD oil from Finland?
  • Orientation for dosing CBD oil dosing table


How much CBD oil needs to be used at one time?


How much CBD oil is needed and worth using? There are large differences in both quality and strength of CBD products and oils on the market. Some of the products are so-called. full spectrum products, ie those that have not been heated or treated to remove active ingredients from the final product. There is also a wide range of board (Spectrum) products on the market, where, for example, some cannabinoids have changed shape as a result of the heating process. Upon heating, the cannabinoid acids are decarbosylated, whereby, for example, the cannabidiol acid CBD-A is converted to the cannabidiol, i.e. CBD. Some products are made entirely from isolates, ie ingredients isolated from hemp, such as CBD alone, in which case the product may contain almost 100% CBD in addition to the carrier oil, without other cannabinoids, terpenes or flavonoids. The isolate is thus a pure laboratory product and does not have as extensive efficacy as a full-spectrum CBD oil. Manufacturers report slightly different dosing recommendations on the packaging of CBD products, as no official recommended intake has yet been defined.

Generally, the recommended dose is 1 to 5 drops once or several times a day. Thus, CBD oil is often dispensed using a pipette in a bottle, making dispensing easy and possible with great precision. However, each person is an individual, so finding the right dose for you depends on a number of different factors such as weight, metabolism, and diet. It also matters whether CBD is ingested with food or on an empty stomach. Recent studies show that CBD can be absorbed more efficiently when ingested with fatty foods (2).


How do I know what the appropriate dose is?


As already mentioned above, the finding of a suitable dosage is influenced by a number of different things and purposes. Manufacturers of CBD oils often state on their packaging general recommendations for the use of the product in drops and milligrams. A good rule of thumb is to start according to the instructions, starting lightly and increasing the dosage a little quietly as needed.

For a completely inexperienced user, it may take some time for the body to become sensitive to the active substances and for the desired effects to begin to appear or be felt. In principle, it is worth using CBD oil as a cure, e.g. For 4 weeks and take a short break if necessary to prevent the tolerance from developing too much.

As tolerance increases, the dosage should also be increased to obtain the same benefits as before. Recommended doses generally range from 3 milligrams to 20 milligrams of CBD, or greater, depending on the product.

In order to find out the best dose size for yourself, it is a good idea to write down the amounts you use so that you can monitor the situation more reliably. Here, too, moderation is a trump card. You can also take advantage of the dose counters made by the manufacturers, if any. Also read how much CBD can be given to domestic animals such as dogs and cats .

The CBD oil dosing table below provides an answer to how many CBD oil drops exactly should you take in proportion to your weight?


CBD dosing table


CBD Oil_Dosage Guide__Dosage Guide_2022_Dosage Lock_Cancer_Anxiety_Migraine_Headaches_Muscle_Recovery_Nausea_Sleep

Dosing of CBD oil for a specific need:

  • Anxiety -> Mild to moderate dosage
  • Epilepsy -> Strong dosage
  • Pain -> Medium or strong dosage
  • Migraine -> From mild to strong dosing
  • Nausea -> Mild to moderate dosage
  • Uneen -> Medium or strong dosage (studies show at least more than 25mg)
  • Cancer -> Strong dosage
  • General health care -> Low dosage

NOTE! No promise of functionality or health effects. Guidance based on user experience.


What factors affect the amount of dosage?


In order to find a suitable dosage, it is a good idea to consider the quality, strength, composition and timing of the CBD oil, i.e. whether the oil is ingested with a meal or on an empty stomach. Often, the appropriate dosage of CBD is assessed based on body weight. Higher doses are recommended for heavier individuals than for lighter ones. Dosage tables and variety dose counters can be found online for both humans and pets (3). The absorption of the active substances in the body varies from user to individual, which is why their duration of action may also vary somewhat. We recommend that you take the following into account when dosing:


1. Things affecting CBD oil


The content and quality of CBD oil is a key factor in the proper dosing of CBD.

QUANTITY OF CBD: There is a wide variety of products available that vary widely in cannabinoid levels. For example, if you are used to using a certain 5% CBD oil, the 5% version from another manufacturer may actually be very different in concentration and effect. That is, sometimes the so-called. a milder product may perform better than a product declared stronger by a different manufacturer. Concentrations of the most common CBD oils on the market vary widely from 1% to 40%. The exact amount of CBD cannot be known except by proper cannabinoid analysis. We always recommend checking product analyzes from your CBD vendor and if they are not available at all, you may want to consider another manufacturer. There may be large differences in the analyzes and measuring instruments and the most reliable analyzes have been performed by a third party. It is therefore not always worth relying on the concentrations reported by the manufacturers alone!

COMPOSITION OF CBD OIL: In general, CBD products on the market are broad-spectrum or full-spectrum products, but sometimes also isolates. The full spectrum includes all active substances in hemp such as cannabinoids (CBD, THC , CBN, CBD, CBDA, etc.), terpenes and flavonoids. A broad spectrum means that in the manufacturing process, some of the ingredients are lost or deformed. By isolate is meant almost pure insulators in crystalline form, i.e., individual active ingredients such as a CBD isolate that does not contain other active ingredients and can be up to 99% CBD at its purest.

Studies show that full-spectrum CBD products perform better than isolates, or a wide range of products, and this interaction is referred to as the “ Entourage effect ” (4). According to some studies, when using isolates, increasing the dose size has not increased the efficacy of the product beyond a certain point.


2. Effects of use


Of course, the time and manner of use will also affect the perceived effects of the CBD oil and the amount of dose required. Others always enjoy CBD oil on an empty stomach right from the morning and another likes to enjoy it with food by mixing it e.g. between food and drink. If the oil is used internally, what matters is how long the CBD oil is allowed to be absorbed from the oral mucosa. The active substances are absorbed into the bloodstream much faster through the blood vessels of the mouth than from the stomach. It is usually recommended to keep the drops under the tongue for 1 to 3 minutes before swallowing. So it is clear that if you mix the drops with the drink then the onset and duration of the effects can be significantly different from allowing it to be absorbed directly under the tongue.

Carriers of CBD oils can also affect how quickly the active substances are transported by the body. Coconut MCT oil, olive oil, sunflower oil or hemp seed oil are often used as carrier oils.


3. Individual factors


It is known that the effect of CBD depends on the individual and, for example, a woman weighing 50 kg and a man weighing 100 kg need a different amount to experience similar effects. The factors affecting the perceived effects are listed in more detail below:

  • MetabolismA: How quickly and for how long CBD affects you depends on e.g. metabolism. So look at whether your metabolism is slow or fast.
  • Body weight: The weight of the user can significantly affect how CBD oil affects your body. A heavier person may need higher doses than a lighter one.
  • Previous experience: When used for a long time, the body may have become accustomed to the effects of CBD oil and the user may experience the effects differently than when they started. Tolerance to active substances may also occur.
  • Gender: According to some studies, CBD and other cannabinoids appear to work slightly differently depending on the user’s gender and hormonal function.


Do you get CBD oil from Finland?


A wide variety of CBD oils can be found in online stores. What they contain and what purpose they are used for affects how the authority views the matter in Finland. In Finland, various CBD products are best found online shopping, health food stores and specialty stores, both as cosmetics and supplements. Products containing CBD can also be ordered in Finland from abroad, and their legality depends on the content, the purpose of the products and how they are marketed. Some products require a prescription in order to order them legally. The legality of all CBD products is assessed on a case-by-case basis.


Cannabinoids and abbreviations

Listed below are abbreviations for some of the best known cannabinoids.





In the article you will find information on how to dispense CBD oil and how to choose the best product for you. The most important factors are the quality and composition of the oil, as well as individual differences such as user weight and metabolism. There are also differences between the products and information of different manufacturers, and it is good to keep in mind that there can be big differences between products, even if the information on the packaging is the same as for another product. For best results, we recommend starting with low doses first and following the manufacturer’s instructions carefully.




  1. SA Millar and others. A systematic review of cannabidiol dosing in clinical populations. 2019. https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.14038 referenced 11.10.2021
  2. Ethan Russo and others. Cannabis and Cannabis Extracts: Greater than the sum of their parts? Journal of Cannabis Therapeutics. 2001. https://www.researchgate.net/publication/228897917_Cannabis_and_Cannabis_Extracts_Greater_Than_the_Sum_of_Their_Parts referenced 11.10.2021
  3. Simona Pisanti. Cannabidiol: State of the art and new challenges for Therapeutic applications . Pharmacol Ther. 2017. https://pubmed.ncbi.nlm.nih.gov/28232276/. Referred to 02.08.2021.
  4. Angela K. Birnbaum , Ashwin Karanam etc. Online Library. Food effect on the pharmacokinetics of cannabidiol oral capsules in adul patients with refractory epilepsy. 2019.
    https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.16093. Referenced 04.06.2021
  5. CBD Dosage Calculator. How much CBD should I take? https://dailycbd.com/en/cbd-dosage/ .
    Referenced 04.06.2021
  6. Sarah Ratliff. Cannabis Tech. The Science Behind the Entourage Effect . https://www.cannabistech.com/articles/what-is-the-entourage-effect-in-cannabis/ . Referred to 02.08.2021
CBD oil and insomnia

CBD oil and insomnia

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CBD oil and insomnia (insomnia) go hand in hand, for most CBD benefit users take CBD oil just in the evenings to calm down, relax, and get a better deep sleep. In this article, we examine the factors that affect sleep and what kind of effect endocannabinoid system and CBD has insomnia.


One third of life is a dream


We sleep an average of a third of our lives. So it is quite clear that what happens during that time has a big impact on how we can stay active. Sleep is a vital function during which the brain rests, the mind calms down and the body is cleansed. (1).

Sleep quality is affected by many different factors such as wakefulness, stress, health, bedding, and bedding. The endocannabinoid system, which maintains the balance of the whole body, also plays a role in the background.

A restful restful sleep should be obtained 6-9 hours a night and during it the body has a huge number of small and large tasks with which it prepares us for the new day. During the night you learn and rest, cleanse and balance. According to the population survey, about a third of Finnish adults suffer from various sleep problems and the same amount worldwide. Sleep problems are either short-lived or chronic and range from long-term insomnia through night sweats to nightmares (1). There are already good therapies for the treatment and symptoms of insomnia and other various sleep problems, both in Western medicine and in complementary therapies, but the interesting and well-proven CBD with therapeutic effects is still a potentially unknown potential sleep aid.

Cannabidiol (CBD) is a therapeutic compound that is not intoxicating. Its relaxing properties are well known and it is already widely used to treat anxiety, pain and depression. Studies have shown that it is also helpful in promoting alertness and reducing drowsiness during the day. So CBD oil can help with sleep problems.


Endocannabinoids are part of the circadian rhythm


Endocannabinoid system is, as it were, a backbone that is not actually responsible for anything, but affects everywhere. There is hardly a single physiological activity in which it would not be involved. Thus, it also plays a very important role in sleep quality and sleep cycle regulation. Not necessarily directly but through the various functions of the body. The endocannabinoid system affects sleep e.g. by regulating the sleep-wake rhythm. (2)

It appears to be responsible for the stability of the sleep-wake cycle, rather than a single function (3). Daily Anandamide variations could play a significant role in the regulation of the sleep-wake cycle. Studies in rats have shown endocannabinoids in biological samples taken e.g. spinal cord, hippocampus, and hypothalamus. In spinal fluid samples, cannabinoid Anandamide concentrations increased during the light period and decreased correspondingly during the dark period. It has been suggested that anandamide would accumulate as a nitrogen cell in the dark and then be released when light enters the spinal cord at those sites that regulate sleep (4). The endocannabinoid system also indirectly affects sleep through knowledge of other bodily functions such as stress levels, metabolism, and pain (5).

Endocannabinoids are a lipid-based network of mediators that act by activating cannabinoid receptors CB1 and CB2. There are receptors almost everywhere in the body. The two most potent cannabinoids, Anandamide and 2-AG, are able to be produced by almost all cells themselves, so there are a huge number of places in the body and brain where the endocannabinoid system can affect sleep (5). The location of cannabinoid receptors in the brain in areas of sleep regulation potentially activates cholinergic neurons. Anandamide – an activated cholinergic neuron expressing the CB1 receptor is known to promote the release of the mediator acetylcholine. Acetylcholine affects e.g. learning and remembering and is released most during deep sleep. This activation could trigger thalamic neuronal activity, which in turn enhances cortical desynchronization. Studies have shown that the function of the brainstem as well as the basal brain in relation to the thalamus is an important element in the regulation of sleep (4).

Fatty acids acting on cannabinoid receptors are known to show diurnal variations in nervous tissues and appear to follow a circadian rhythm (3). It has also been observed that they could act as zeitges, i.e. affect our internal clock (5). When these findings are combined with the knowledge that the endocannabinoid system maintains the body’s general equilibrium and regulates various bodily functions in the direction of equilibrium, it is clear that transient or chronic cannabinoid deficiency or endocannabinoid imbalance is inevitably reflected in sleep quality.


CBD oil to support sleep


Our bodies produce the necessary cannabinoids themselves, but we can help balance the cannabinoid system by utilizing plants that are naturally abundant. cannabinoids . Hemp is known to have more than 100 different cannabinoids and the best known and most studied of these are THC and CBD . Different hemp varieties produce different amounts of different cannabinoids that respond to the cannabinoid receptors in our body. (6)

Psychoactive THC mainly responds to the CB1 receptor. The topic has been extensively studied in cannabis and sleep research since the 1970s, although it was not yet a direct study of the cannabinoid receptor (5). It has been observed that long-term cannabis (THC) users experience sleep problems, especially during weaning, and that THC use easily becomes a twist specifically related to sleep (6).

Non-intoxicating CBD responds to the CB2 receptor. It has been said that CBD has many positive effects on us. It lowers the inflammatory state of the body and, if necessary, also acts like pharmacological drugs, e.g. as an anti-acceleration and antiemetic drug. In the absence of solid evidence for the role of CBD in sleep regulation, the following hypothesis has been put forward; CBD enhances c-Fos gene expression in the hypothalamus as well as in the Raphe nucleus, both of which play a significant role in sleep production (7). Dosage appears to play a very important role in the success of treatment of sleep problems. A low dose accelerated subjects and made sleep more difficult, whereas at a higher dose, sleep problems were significantly alleviated (8). CBD is non-intoxicating, so it has a calming and stress-reducing effect on us.


Studies on how CBD helps with insomnia


There has been relatively little research on cannabinoids and sleep alone. Research on the CBD’s help with insomnia has only begun to attract researchers in recent years. Cannabis and sleep have been studied again since the 1970s, but cannabinoids and sleep only after 1990. Cannabis-related research has provided an excellent basis for more sophisticated research into the endocannabinoid system today (5). The results of research on cannabinoids and sleep have been obtained mainly in connection with other studies, but the relationship between cannabinoids and sleep itself has also been studied to some extent.

Research has been done in both humans and English bulldogs (6), but the results obtained with rats and other rodents help us better understand the effect of cannabinoids on sleep. The sleep of rodents is very similar to that of humans and samples and information can be collected from them at all stages of the sleep cycle (6). A study of sleep apnea in rats found that cannabinoids play an important role in achieving autonomic balance during sleep. Rats were given two cannabinoids (THC and Oleamide) and serotonin, all simultaneously and separately. These cannabinoids were also found to have an effect on the development and treatment of sleep apnea (5).

It is possible that studies with both different CBD products and THC preparations will give a placebo effect on the results due to the awareness of the medicinal effects of cannabis. Nevertheless, several studies have shown that CBD products in particular, when found in the right dose size, are highly effective, well tolerated, and safe. Studies have not shown any bad side effects and as a general rule, those treated have found CBD products pleasant and favorite to use!


Summary and concluding remarks


There has been so little research on the endocannabinoid system, cannabinoids and sleep that it is not yet possible to say for sure how it will affect the treatment and symptoms of insomnia, but what is certain is that it is of great importance. The results are contradicted by the fact that there are more than 100 different cannabinoids and that the individual effect of all of these is not yet known. Most studies focus mainly on THC and CBD cannabinoids and the effect of these on us is very different. However, it is undeniable that the endocannabinoid system plays a very important role in sleep and sleep quality through many different functions. A more holistic understanding of it would make a significant contribution to the treatment of many diseases and open up more to the subtle functioning of the human body. Experiences in human use and research findings on the positive effects of CBD on sleep are a gratifying perspective on the ever-increasing variety of insomnia symptoms.


Source list:


  1. Current care recommendation. Published 6/26/2020 https://www.kaypahoito.fi/hoi50067 Referred to 31.3.2021
  2. Russo, E. 2015. Introduction to the Endocannabinoid System. PHYTECS. https://www.phytecs.com/wp-content/uploads/2015/02/Russo-Introduction-to-the-Endocannabinoid-System-corr-January-2015.pdf Referenced on March 31, 2021
  3. Kesner AJ & Lovinger DM 2020. Cannabinoids, endocannabinoids and sleep https://www.frontiersin.org/articles/10.3389/fnmol.2020.00125/full Referenced on March 31, 2021
  4. Murillo-Rodriguez E. 2008. The role of the CB1 receptor in the regulation of sleep https://pubmed.ncbi.nlm.nih.gov/18514375/ Referenced 5.4.2021
  5. Babson KA & Sottile J. & Morabito D. 2017. Cannabis, Cannabinoids, and Sleep: a Review of the Literature https://www.med.upenn.edu/cbti/assets/user-content/documents/s11920-017-0775-9.pdf Referenced 5.4.2021
  6. Carley DW & Paviovic S. & others. 2002. Functional role for cannabinoids in respiratory stability during sleep https://pubmed.ncbi.nlm.nih.gov/12071539/ Referenced 31.3.2021
  7. Murillo-Rodriguez & others. 2014. Potential effects of cannabidiol as a wake-promoting agent https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023456/ Referenced 31.3.2021
  8. Shannon S. & others. 2019. Cannabidiol in anxiety and sleep: a large case series https://pubmed.ncbi.nlm.nih.gov/30624194/ Referenced 31.3.2021
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