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Focus and CBD

Focus and CBD

The phone beeps to signal a new social media post. An email will follow. There are footsteps coming from the corridor and the colleague sitting at the next table is laughing, possibly at a funny video he just saw. The summer’s most played hit is playing on the radio and thoughts are already turning to next week’s menu. Attention is drawn to everything else except what you should be doing, and it’s no wonder! Lack of concentration is one of the biggest challenges of today. It is understandable, because the flood of stimuli in the environment is huge.

Is good concentration a gift given at birth, or can it be improved when it is impaired? In this article, we will get to know what concentration is, how it can be supported and whether CBD oil could help with this!

 

What is focus?

 

Focusing is paying attention and concentrating on what is being done and what is essential in terms of the operation.

When you are deeply focused, you lose track of time, you immerse yourself in what you are doing and things seem to flow naturally. As a result of concentration, the quality of work improves, learning deepens and thinking can develop.

The background is the activity in the frontal lobe of the brain and concentration is the cooperation of the brain and nervous system. The frontal lobe matures until the teenage years, and the nerve connections related to concentration can be strengthened throughout childhood. The brain is plastic, which means it can change throughout life. The ability to concentrate can also be improved when it weakens.

The central nervous system’s neurotransmitter, dopamine, is central to brain activity related to concentration. Dopamine is produced not only in the brain but also in the gut and it carries signals between brain cells. Dopamine especially affects concentration, motivation, movement and the feeling of pleasure, as well as sleep, emotion regulation and energy balance. It also improves the general functioning of the brain. (1)

 

Difficulty concentrating

 

Difficulty concentrating is not uncommon and everyone has it at times. There may be other challenges in the background such as ADHD , depression or stress , but the flood of environmental stimuli that strongly affects concentration unfortunately touches and challenges everyone. Life is hectic and there is a lot to think about, instant videos are watched for hours a day and work and studying are interrupted by the disturbances coming from this environment. It’s as if the brain has already learned that the required time to focus on one thing is very short, and that’s why fidgeting is a weakness of the neural connection.

Poor concentration shows up as interruptions in thought. It seems that he does not understand what is being said, what is meant by the text, and even familiar tasks seem more difficult than they really are. My mind wanders somewhere else and it’s hard to get a grip on what’s going on.

The fast rhythm of life and the stimuli in the environment have made it very common for children and adults alike to have poor concentration. Concentration challenges are already common enough that its symptoms have their own term, attention deficit disorder (ADT).

 

Attention Deficit Disorder (ADD) is a disorder that affects the ability to concentrate due to a flood of stimuli.

Attention Deficit Disorder (ADD) reflects difficulty concentrating due to a constant barrage of stimuli.

 

ADT stands for Attention Deficit Disorder

 

ADT (Attention Deficit Trait) or concentration disorder is a relatively new term and it refers to the so-called self-acquired difficulty concentrating. R. Hallowelli, an American psychiatrist who treats ADHD patients, noticed that people suffering from hyperactivity, i.e. ADHD symptoms, but who do not have ADHD, i.e. a neurological abnormality in brain function, are coming to his office. He interpreted that they have self-acquired attention deficit disorder instead of congenital ADHD and coined the term Attention Deficit Trait (ADT) to describe the symptomatology. ADT is precisely difficulty concentrating caused by a flood of stimuli. (2,3)

 

Developing a child’s ability to concentrate

 

The frontal lobe continues to mature until adolescence, so childhood is a good time to pay attention to the development of concentration. When life is fast-paced, it is important to stop in peace at the edge of doing things and give the child experiences of moments where there are no distractions. Memory games, long-lasting role plays, crafts and arts, etc. help the child focus on one thing and strengthen the nerve connections needed for concentration. (4,5)

 

Concentration can be improved

 

Concentration can be improved in many ways, e.g. with supplements that support it. Magnesium is one of the most important minerals for the body and its deficiency is very common. Taking a good magnesium supplement can have a positive effect on the ability to concentrate and you can read about it more here. Similarly, e.g. L-theanine , the effects of which can be read here .

From the plant ashwagandha (herbaceous plant) and Ginkgo Bilopa (maiden hair tree) can also help with concentration. In addition to these, medicinal mushrooms such as lion’s mane can be helpful.

Vitamins of the B group obtained from food and glucose, a monosaccharide belonging to carbohydrates, are the most significant in terms of concentration. B group vitamins are most abundant in e.g. in beans, sprouts, dairy products and nutritional yeast flakes. Glucose e.g. in dried fruit, fresh fruit and dried fresh vegetables such as carrots. (6)

The ability to concentrate can also be improved by practicing concentration. As with children, an adult’s concentration is also improved by such hobbies that require concentration and deepening. Reading a book, doing crafts, learning new skills, etc. put the brain to work and help in the formation of new nerve connections.

 

Supporting concentration

 

Concentration can be supported by taking care of general well-being. A life as stress-free as possible, exercise, a sufficient amount of good sleep , clean and nutritious food, and moments without smart devices provide a good basis for the ability to concentrate, but it should also be supported with, for example, conscious stopping. Daily moments when you just be, listen and observe and don’t do or think about anything, help the nervous system to calm down and create new connections.

Concrete actions at the workplace and at school can also increase the possibility of concentration. You can’t always change the environment, but by openly discussing the need for peace of mind at work and, for example, by using noise canceling headphones, you can achieve the desired peace for your own work.

The ability to concentrate can be improved with music. Rhythmic music has been scientifically proven to help you concentrate better.

According to research, listening to rhythmic music improves concentration.

 

Music affects concentration

 

Many people know from experience that music deepens the effect, and this is also confirmed by research. Others need a little noise in the background of their work, while others need silence, but mostly rhythmic music supports everyone’s concentration. According to American research, it is not so much the tempo or nature of the music that is important, but the rhythm in it. (7,8)

 

The endocannabinoid system underlying attention

 

The endocannabinoid system is a balancing system of the human body, whose task is to ensure that all bodily functions take place correctly and on time. The endocannabinoid system consists of endo- or internally-born cannabinoids, cannabinoid receptors and the enzymes that break them down.

Endocannabinoids are formed in many places in the body, but usually only when needed. There are two known endocannabinoids, anandamide and 2-AG . In the background of concentration, they influence e.g. dopamine production (9) and brain function (10).

Cannabinoids to support concentration

 

The hemp plant contains many different active compounds, the most familiar of which are cannabinoids. There are more than 120 different types of cannabinoids and this is probably the most famous CBD ( cannabidiol). Other cannabinoids have also been studied and, apart from CBD, CBG or cannabigerol may have the greatest effect on concentration.

CBD oil is extracted from hemp and, according to research, it has numerous properties that affect the well-being of both humans and animals. In the background of concentration, cannabidiol, or CBD, may have a positive effect sleep quality , which you can read more about here. Sstress, which you can read about the interaction with CBD here, and depression, which you can read more about here . According to studies, cannabidiol also has calming effects on the nervous system.

CBD may not directly affect the ability to concentrate, but by helping the body towards balance, its effects most likely extend there as well. The brain plays a significant role in the background of concentration, and according to research, CBD increases blood circulation in those areas where e.g. learning and remembering takes place. (11)

 

Summary

 

Poor concentration is a common challenge for people of all ages, but there is an opportunity to improve it. There are many ways, but it is also important to stop and think about what might be the cause of poor concentration, so that you can rule out other possible causes such as depression, ADHD or other diseases affecting concentration. Concentration can be supported by e.g. by strengthening the nerve connections necessary for concentration, and with the help of versatile nutrition, supplements and quality sleep. Also CBD oil may be helpful for increasing and maintaining concentration. A new large-scale American study is currently underway on this topic, which will lead to a better understanding of activities related to concentration in the future (12).

 

Sources

 

  1. Wium M.. 2022. Science photo magazine. Dopamine – a multifunctional pleasure substance. https://tieku.fi/ihminen/elimisto/dopamine. Referenced 10/6/2023.
  2. Student Health Care Foundation. ADHD or even ADT? https://www.yths.fi/terveystieto/mielenterveys/keskittyminen/adhd-vai-sittenkin-adt/. 6.10.2023.
  3. Edward Hallowell. 2005. Harvard business review. Overloaded Circuits: Why Smart People Underperform. https://hbr.org/2005/01/overloaded-circuits-why-smart-people-underperform. Referenced 10/6/2023.
  4. Mannerheim Child Welfare Association. Supporting the ability to concentrate. https://www.mll.fi/vanhemmille/tietoa-lapsiperheen-elamasta/hyvinvointia-digiajassa/vauvana-ja-taaperona-digiajassa/median-vaikutuksista-pienen-lapsen-elamassa/keskittymiskyvyn-tukeminen/. Referenced 10/6/2023.
  5. Learning and Joy. Temper increases with age – this is how you support a child’s concentration and self-regulation skills. https://www.oppijailo.fi/tue-taitoja-nain-keskittymiskyky-ja-itsesaatelytaidot-kehittyvat. Referenced 10/6/2023.
  6. Fine. Department of Health and Welfare. Nutritional values. https://fineli.fi/fineli/fi/elintarvarkei . Referenced 10/6/2023.
  7. Hogenes M., Van Oers B., Diextra R. and Sklad M.. 2015. The effects of music composition as a classroom activity on engagement in music education and academic and music achievement: A quasi-experimental study. https://www.researchgate.net/publication/279160129_The_effects_of_music_composition_as_a_classroom_activity_on_engagement_in_music_education_and_academic_and_music_achievement_A_quasi-experimental_study. Referenced 10/6/2023.
  8. Stammeier J. and Wiksten A.. 2019. Too much noise? Is it difficult to concentrate?. https://yle.fi/aihe/artikkeli/2019/12/20/liikaa-melua-ja-halya-onko-keskittytymen-vaikeaa-tietyntyptinen-musiikki. Referenced 10/6/2023.
  9. Covey D., Mateo Y., Sulzer D., Cheer J., and Lovinger D.. 2017. Endocannabinoid modulation of dopamine neurotransmission. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608040/. Referenced 10/6/2023.
  10. Zou S. and Kumar U.. 2015. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/. Referenced 10/6/2023.
  11. Bloomfield M., Green S., et al.. 2020. Sage Journals. The effects of acute cannabidiol on cerebral blood flow and its relationship to memory: An arterial spin labeling magnetic resonance imaging study. https://journals.sagepub.com/doi/full/10.1177/0269881120936419. Referenced 10/6/2023.
  12. Laura Stewart, University of Northern Colorado. Cannabidiol and Focus Study (CBD-Focus). https://clinicaltrials.gov/study/NCT05189275#publications. Referenced 10/6/2023.
CBN, CBG and CBD differences

CBN, CBG and CBD differences

What are CBN and CBG? How are they different from CBD? In this article you will find information about the differences and properties of these cannabinoids.

 

What is CBN and CBG?

 

CBN and CBG are cannabinoids, i.e. chemical compounds found in hemp plants.

CBN (cannabinol) is one of the main cannabinoids in cannabis, also known more commonly as the “sleep cannabinoid”. It is formed from THC (tetrahydrocannabinol) as a result of oxidation when cannabis is exposed to air or light for a long period of time. CBN is also believed to have sedative and sleep-promoting properties. Based on research, CBN is also antibacterial and can help reduce inflammation and improve appetite. (1)

CBN is also the first cannabinoid ever isolated from hemp, isolated by American chemist Roger Adams in the 1940s. (2)

CBG (cannabigerol) on the other hand, there are cannabinoids that appear first in hemp. First comes CBGA, which forms compounds including CBG, THC, CBD and other cannabinoids are later synthesized. (3)

CBG has a versatile action profile and has been associated with several potential therapeutic properties, such as anti-inflammatory and analgesic properties, as well as antibacterial properties . CBG is not a psychoactive compound, i.e. it does not cause a narcotic effect. (4) In addition, studies show that CBG has effects that reduce tumors and cancer cells (5).

CBG was first identified in 1964 by Raphael Mechoulam and Yehil Gaon. (6)

Both compounds, CBN and CBG, have received increasing attention in cannabis research due to their potential therapeutic benefits. However, it is important to note that studies on the effects and application of these compounds are still in progress and more information is needed

 

How do CBN and CBG differ from CBD?

 

CBN, CBG, and CBD are all cannabinoids found in the hemp plant, but they have slightly different chemical structures and effects. A few differences between these compounds are highlighted below:

CBD or cannabidiol does not cause an intoxicating or psychoactive effect. It does not alter consciousness or cause a feeling of euphoria. Also, CBG is not a psychoactive compound, and it does not cause a narcotic effect at all.

CBN is formed when THC breaks down over time with oxygen, heat and time. The CBN content of hemp increases as the THC breaks down and disappears. Because CBN is formed as a result of the oxidation of THC, it has been found to have mild psychoactive properties. Together with CBD, however, the psychoactivity is reduced to non-existent, as CBD has antipsychotic effects. Many CBN products also contain CBD. (1)

CBG (cannabigerol) in its acid form (CBG-A) is the first cannabinoid from which other cannabinoids are also formed.

 

Therapeutic properties of cannabinoids

 

CBD, CBN, and CBG have various potential therapeutic properties. The effects may also vary depending on individual characteristics and health status. The cannabinoids in question work to the internal cannabinoid system either directly or indirectly.

CBD is known to have properties such as anti-inflammatory, pain-relieving, anxiety-reducing and spasm-reducing. (7)

CBN is believed to have particularly sedative and sleep-promoting properties.

CBG acts through CB1 and CB2 receptors and has been found to have antibacterial, appetite improving, pain and inflammation relieving, and antioxidant effects. CBG is also believed to have mood-enhancing effects, as it increases the amount of serotonin in the body. (8)

According to recent studies, CBG has been found to have positive effects on certain diseases such as cancer, inflammatory bowel disease (IBD), bacterial infections and Huntington’s disease. (9, 10, 11)

 

Cannabinoids in hemp. Image of an article about the differences between CBN, CBG and CBD.

Hemp field in the flowering phase.

 

Cannabinoid concentrations in hemp

 

Cannabinoids such as CBN, CBG and CBD occur naturally in hemp in varying amounts. The amounts vary greatly in different varieties. The growing season, environment and other conditions can also affect the concentrations formed in the plant. More than 120 different cannabinoids have already been identified in hemp, and it is known that cannabinoids work together better than individually (see Entourage effect ).

CBD is generally more abundant in hemp plants than CBN or CBG. CBN, on the other hand, is formed as a result of the oxidation of THC over time, so it is usually less present in young plants. CBG is the main cannabinoid in the early development phase of cannabis, the presence of which decreases significantly towards the end of the growing season.

There are many varieties of hemp with different cannabinoid profiles. Nowadays, varieties are also being bred that can contain a certain amount of a particular cannabinoid, being very different from the averages in terms of their cannabinoid profile compared to other common hemp varieties.

 

What are cannabinoid acids such as CBGA, CBNA and CBDA?

 

The cannabinoids found in hemp are always initially in acid form, such as CBGA (cannabigerolic acid) and CBDA (cannabidiol acid). The letter A after the name of the cannabinoid refers to its acid form (Acid).

 

CBGA

 

CBGA (cannabigerolic acid) and CBNA (cannabinolic acid) are acid forms of cannabinoids that occur in hemp before they are converted to active compounds such as CBG and CBN through acid decarboxylation or oxidation.

CBGA is the acid form of CBG, the first cannabinoid formed in hemp. CBGA is usually present in the cannabis plant in large amounts in the early growth phase, before the plant produces any other cannabinoids. CBGA is converted to other cannabinoids, such as CBDA (cannabidiol acid) or to THCA (tetrahydrocannabinolic acid), over time, through oxidation or carboxylation reactions.

 

CBNA

 

CBNA, on the other hand, is the acid form of cannabinol acid that is present in the cannabis plant before it is converted into the active compound, CBN. CBNA is formed from the THCA of the cannabis variety as a result of oxidation. When THCA is exposed to air or light over time, it oxidizes and turns into CBNA. This process can occur when the plant is stored for a long time or poorly stored in non-airtight packaging.

CBNA and CBGA act as precursors from which other active cannabinoids such as CBG and CBN are formed, which are known to affect the body in many different ways.

 

CBDA

 

CBDA is a precursor to CBD and according to research it is a powerful antioxidant. CBD has versatile effects, the most significant of which are e.g. the following:

  • Anti-nausea (12)
  • Anti-inflammatory (12)
  • Pain reliever (12)
  • Cancer prevention (13)

In addition to these, CBDA has antimicrobial, antiproliferative, and antibacterial properties.

 

Summary

 

CBD, CBN and CBG are the most well-known cannabinoids, which are found especially in the leaves and flowers of hemp plants. These cannabinoids have a balancing effect on the body’s endocannabinoid system, and although they resemble each other, each of them has its own special properties. All cannabinoids are first formed from CBGA, which is the precursor or acid form of cannabigerol (CBG).

Cannabinoids have versatile effects that vary individually depending on the characteristics and health status of the user. According to research, different cannabinoids are more effective together than individually, and this combined effect is also called the Entourage effect.

It is important to note that the information presented in this article is based on general observations and research results. Research into the effects of cannabinoids is still ongoing, and their full potential and all the possibilities of its use are not yet completely clear, because it is a very versatile and unique plant.

 

Sources

 

  1. L Bianco. 2018. GB Sciences Inc. Exploring the Lesser Cannabinoids – The Happy Accident of CBN. https://www.biospace.com/article/releases/exploring-the-lesser-cannabinoids-the-happy-accident-of-cbn/ . Referred on 07/13/2023
  2. R. Pertwee. 2006. Cannabinoid Pharmacology: the first 66 years. Br. J Pharmacol. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760722/. Referenced 07/14/2023
  3. Tahir M. et al. 2021. The biosynthesis of the cannabinoids. Journal of Cannabis Research . https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-021-00062-4 . Referenced 07/14/2023
  4. RG. Pertwee. 2010. British Journal of Pharmacology. Evidence that the plant cannabinoid cannabigerol is a highly potent a2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist. https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2009.00515.x. Referenced 07/14/2023
  5. F. Borrelli ym. 2014. Carcinogenesis. Colon Carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid . ncbi.nlm.nih.gov/pubmed/25269802 . Referenced 07/14/2023
  6. Gaoni, Y., & Mechoulam, R. 1964. Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish. Journal of the American Chemical Society, 86(8), 1646–1647 . https://doi.org/10.1021/ja01062a046 . Referred on 07/13/2023.
  7. EB Russo. Cannabidiol (CBD) claims and misconceptions. Trends in Pharmacological Sciences. https://pubmed.ncbi.nlm.nih.gov/28089139/ . Referred on 07/13/2023.
  8. M. Lee. 2012. The Discovery of the Endocannabinoid System. The Prop 215 Era. https://www.beyondthc.com/wp-content/uploads/2012/07/eCBSystemLee.pdf. Referred on 07/13/2023.
  9. S. Valdeolivas etc. 2015. Neurotherapeutics. Neuroprotective properties of cannabigerol in Huntington’s disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice . ncbi.nlm.nih.gov/pubmed/25252936 . Referred on 07/13/2023
  10. F. Borrelli ym. 2013. Biochem Pharmacol. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease . https://pubmed.ncbi.nlm.nih.gov/23415610/ . Referenced 07/14/2023
  11. A. Maya ym. 2020. Science Daily. Researchers uncover hidden antibiotic potential of cannabis. https://www.sciencedaily.com/releases/2020/02/200226131325.html . Referenced 07/14/2023
  12. D. Butterfield. Cannabidiolic Acid (CBD -A): The Raw Cannabinoid That Fights Inflammation. http://herb.co/2017/05/20/cbda/ . 2017. referenced 07/14/2023
  13. S. Takeda Ym. Cannabidiolic acid (CBD -A) mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness. https://www.ncbi.nlm.nih.gov/pubmed/27530354 . 2017. Referenced 07/14/2023
What is CBG?

What is CBG?

CBD products are growing in popularity and new hemp products such as CBG oil and CBN oil have recently entered the market with a lot of interest. This article discusses what CBG or cannabigerol is.

 

CBG or cannabigerol


CBG is one cannabinoid compound found in hemp that has been studied more than ever in recent years. The phytocannabinoid CBG is non-narcotic, meaning it does not cause intoxication to the user. CBG acts on the same receptors as CBD (1).

Despite the fact that coverage of cannabiger is still significantly lower than that of the best-known CBD and THCAccording to new studies, it has similar effects to CBD in addition to its unique properties. CBG is also classified as safe for daily use. Thus, CBG could very well be a new rising and trendy cannabinoid product.

 

CBG increases serotonin secretion

 

CBG, like other cannabinoids, acts on the body’s internal cannabinoid system through cannabinoid receptors (CB1 and CB2). Studies show that CBG increases serotonin, the so-called well-being hormone secretion, which has a mood-boosting effect.

CB1 and CB2 receptors play an active role in the regulation of cognitive functions such as appetite, pain response, mood, and internal balance. By acting on cannabinoid receptors, cannabinoids can alter the signals that neurotransmitters send to the body to maintain the balance of vital functions (2).

 

Use of CBG in various diseases

 

According to the latest research, CBG has versatile effects on well-being. It is used especially for certain diseases.

 

Pain

 

According to research, the cannabinoid CBG (cannabigerol) can reduce pain because it is a potent alpha-2-adrenoceptor agonist and also a moderately potent 5HT1A receptor antagonist. (3)

 

Cancer

 

A 2014 study looked at colon cancer in rats and concluded that CBG may reduce the growth of cancer cells and other tumors. (4)

 

Huntington’s disease


CBG has neuroprotective properties. A 2015 study looked at mice with a neurodegenerative disease called Huntington’s disease. The study concluded that CBG may also be promising in the treatment of other neurodegenerative diseases. (5)

 

IBD (Inflammatory Bowel Disease)


According to a 2013 study, CBG appears to reduce IBD symptoms. In summary, the study shows that CBG attenuated colitis in mice, reduced nitric oxide production in macrophages, and reduced ROS formation in intestinal epithelial cells. CBG could be considered for clinical trials in IBD patients. (6)

 

Bacterial infections


The study found that CBG can kill bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA), which causes drug-resistant infections. These infections can be difficult to treat and also sometimes dangerous. (7)

In addition to the benefits listed above, CBG has been found to have an effect on improving appetite and many other ailments, which need further research for confirmation.


The CBG was discovered as early as 1964


CBG is not in itself a new discovery. The CBG was first identified from hemp in 1964. The compound was discovered together by researchers Raphael Mechoulam and Yehil Gaoni (8).

However, isolating CBG from hemp is not as easy as isolating CBD, which has made the launch of CBG products slower and more laborious. Now, several manufacturers have invented ways to extract CBG efficiently. At the moment, there are e.g. CBG oil, CBG capsules, CBG cosmetics, CBG candies, CBG flowers and more. CBG products.

 

CBG is the mother of all cannabinoids

 

CBG is called the mother of all cannabinoids, as CBG forms all other hemp cannabinoids. CBG is also known as the cannabinoid stem cell and the “Rolls Royce” of cannabis.

Like all other cannabinoids, CBG is present in hemp in acid form (CBG-A). Enzymes allow cannabigeric acid (CBG-A) to form other better-known cannabinoid acids such as THC-A and CBD-A, which in turn transform over time into THC, CBD and other non-acidic cannabinoid compounds (9). Finally, the remaining CBG-A (approximately 1%) decarboxylated CBG. A total of at least 120 different cannabinoids have been found in hemp.

 

What effect does CBG have in combination with other medicines?

 

It is not yet known what interactions CBG may have with other medicines.

If you are taking any medications, it is best to check compatibility with your doctor before trying CBG oil. This is especially important if you are taking a medicine that contains so-called grapefruit warning. ​​In the same way as grapefruit juice, CBG can also increase the effectiveness of the effects of several drugs.

 

Medicines that often have this warning include:

  • antibiotics and antimicrobials
  • anticancer drugs
  • antihistamines
  • antiepileptics (AEDs)
  • antihypertensive drugs
  • blood thinners
  • cholesterol drugs
  • corticosteroids
  • erectile dysfunction drugs
  • gastrointestinal (GI) medicines such as gastroesophageal reflux disease (GERD) or nausea
  • antiarrhythmics
  • immunosuppressants
  • antidepressants such as for anxiety, depression or mood disorders
  • painkillers
  • prostate medications (10).

 

List of drugs with interactions

 

See a more detailed list of drugs commonly used in Finland that have been shown to interact with CBD.

CBD can affect how your body metabolises these medicines. It’s not clear if CBG has the same effect, but given how similar it is to CBD, it’s best to be cautious and carefully consider co-medications. (10)

Do not stop taking your medication to use CBG oil unless instructed to do so by your healthcare professional.


Require third-party analysis

 

When choosing CBG products, you should first check that the company’s products are tested and trusted by a third party. Check the cannabinoid profile and possible contaminations for analysis. All analyzes should be available on the vendors ’website or should at least be available via email upon request.

 

Sources

 

  1. G. Navarro et al. 2018. Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1 – CB2 Heteroreceptor Complexes. Front Pharmacol.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021502/
  2. M. Lee. 2012. The Discovery of the Endocannabinoid System. The Prop 215 Era.
  3. RG. Pertwee. 2010. British Journal of Pharmacology. Evidence that the plant cannabinoid cannabigerol is a highly potent a2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonistbph_515 129..141. https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2009.00515.x. Referred to 31.01.2023
  4. F. Borrelli ym. 2014. Carcinogenesis. Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. ncbi.nlm.nih.gov/pubmed/25269802. Referred to 31.01.2023
  5. S. Valdeolivas etc. 2015. Neurotherapeutics. Neuroprotective properties of cannabigerol in Huntington’s disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice. ncbi.nlm.nih.gov/pubmed/25252936. Referred to 31.01.2023
  6. F. Borrelli ym. 2013. Biochem Pharmacol. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. https://pubmed.ncbi.nlm.nih.gov/23415610/. Referred to 31.01.2023
  7. A. Maya ym. 2020. Science Daily. Researchers uncover hidden antibiotic potential of cannabis. https://www.sciencedaily.com/releases/2020/02/200226131325.html. Referred to 31.01.2023
  8. Gaoni, Y., & Mechoulam, R. 1964. Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish. Journal of the American Chemical Society, 86 (8), 1646–1647. https://doi.org/10.1021/ja01062a046
  9. Tahir M. et al. 2021. The biosynthesis of the cannabinoids. Journal of Cannabis Research. https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-021-00062-4 . Referenced on 19.11.2021
  10. S. Ferguson. 2020. Healthline. Meet the CBG, the New Cannabinoid on the Block.
    https://www.healthline.com/health/cbg-oil#interactions. Referenced on 11/18/2021.
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