Want to know if CBD oil has side effects? This article has compiled the most common information about the side effects that some people may experience from using CBD oil. Possible side effects are always case-specific and are affected by many factors such as the characteristics of the user (weight, metabolism, diseases), as well as the quality of the CBD oil or CBD products used.
What are the side effects of using CBD oil or can there be?
Although there are generalizations that give direction about the side effects of CBD, each user reacts to it in their own way and based on the situation that the user has at any given time. The individual’s effects on CBD products cannot be predicted with certainty until it has been tried. We therefore recommend always starting the use of CBD oil with the lowest possible dosage and increasing the dosage slowly by observing your own situation for a couple of weeks.
According to a study conducted in 2017, the most commonly reported side effects were fatigue, diarrhea and changes in appetite and weight. Compared to other drugs used to treat these conditions, CBD has fewer side effects (1).
Below you will find a more detailed list and comments on the most common side effects that the use of CBD may have in some cases.
Some users experience some degree of fatigue after consuming CBD products. At the same time, many also feel that CBD helps them fall asleep and deepen sleep, so fatigue cannot be considered a direct harmful effect.
If you find CBD too tiring, you can try to reduce the dosage a little and monitor your situation again. The experience of fatigue may change after using CBD products for a longer period of time. The recommendation is to start using it with the smallest possible dosage and increasing it as needed when the body is used to its effects.
Dry mouth is one of the most common side effects caused by CBD. Cannabidiol or CBD affects the receptors in the salivary glands and may temporarily reduce saliva production. However, dry mouth is not harmful and can be easily prevented by drinking fluids such as water when necessary.
Changes in appetite
Side effects related to experiencing appetite are fairly common with CBD oil. Factors affecting appetite are above all mental and physical well-being, which may also be affected by the use of CBD. Depending on the situation, CBD products may increase or decrease appetite. If you experience unwanted effects on your appetite, you should try reducing the dosage of CBD oil until your appetite returns to normal.
Changes in blood pressure
The use of CBD oil may cause a decrease in blood pressure. Sometimes it can go completely unnoticed, and that’s why especially those suffering from health problems should monitor their blood pressure regularly if they want to use CBD products. If you are concerned about the use of CBD and the possible lowering of blood pressure, we recommend that you discuss the matter with your doctor before using CBD products.
In some cases, diarrhea has been observed as a side effect of CBD oil. Diarrhea may also be affected by using the carrier oil in CBD oil into which CBD has been extracted.
The carrier oil is usually olive oil, hemp oil or MCT oil obtained from coconut, whose function is to improve the absorption of cannabinoids in the body and to bring additional nutrients to the product. In some cases, certain oils may irritate the mucous membranes of the stomach, and therefore it is recommended to start dosing as carefully as possible and consider changing the carrier to another, if diarrhea occurs repeatedly as a side effect.
What are the side effects of CBD oil when used in combination with medications?
CBD is often used as a complementary treatment. Therefore, more clinical research is needed on the effect of CBD on liver enzymes, drug transporters and interactions with other drugs and to determine whether it causes mainly positive or negative effects, for example by reducing the necessary doses of clobazam in epilepsy and thus the side effects of clobazam.
Together, the combination of certain medicinal substances and CBD may increase or decrease the effectiveness of the medicine in a significant way. If you use certain products belonging to the pharmaceutical group below, we recommend discussing the use of CBD products together with your doctor.
CBD affects the user through cannabinoid receptors and the substance is removed from the body mainly through the liver. An enzyme called cytochrome p450 is essentially related to the metabolism of CBD and the use of CBD can increase the activity of these enzymes in the body. These CYP enzymes are everywhere in the body, especially in the liver. CYP enzymes also have a central effect on the behavior of other medicinal substances in the body, i.e. CBD and certain medicinal substances can reduce or increase the effectiveness of the medicine in a sometimes dangerous way (2).
According to the study, not all interactions have been studied yet. So more clinical trials with a larger number of participants are needed. Read more about the possible interactions of CBD oil with drugs commonly used in Finland in our article “ The effect of CBD oil with drugs “.
What is safe CBD oil?
Safe CBD oil is always made from high-quality and pure raw materials and extracted using safe methods such as carbon dioxide extraction without additional solvents. Safety is also significantly increased by third-party laboratory analyzes of the contents of the products. Such analyzes include e.g. cannabinoid profile, heavy metal and contamination analyses.
If you’re looking for safe CBD oils, we recommend checking out the selection in our online store. In the online store, you can find third-party analyzes of the products and more information on the use and manufacture of CBD.
- K. Iffland & F. Grotenhermen. 2017. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/. Referred on 31.08.2021
Johns Hopkins University. Clinical Trials. Interactions Between Cannabinoids and Cytochrome P450-Metabolized Drug. https://clinicaltrials.gov/ct2/show/NCT04201197. Referred to on September 1, 2021