CBD, Immunity and Autoimmune Diseases

CBD, Immunity and Autoimmune Diseases

Autoimmune diseases are increasing rapidly. There are more than 100 different autoimmune diseases and it is estimated that around five percent of the population has an autoimmune disease. Autoimmune diseases are often challenging to treat, and there is not always an effective medicine for them. In this article, we look at immunity, autoimmune diseases and whether CBD has an effect on them.

 

Natural immunity

 

Immunity is a natural synergistic ensemble of the body’s defense systems, which includes all defense and protection systems that protect us from various physical external harms, such as bacteria, viruses, parasites and harmful microbes. The most important function of the immune systems is to divide the elements moving in the body into own and foreign, threats and safe.

Immunity builds up strong already during childhood forest trips. It is important to be exposed to microbes as widely as possible from early childhood, because the phenomenon called the hygiene hypothesis can already be seen. The hygiene hypothesis means that people who grew up in too clean an environment are more prone to allergies and e.g. for asthma because they have not had enough contact with different microbes and pathogens so that the body could have created a strong immunity when encountering them (1).

Immune system dysfunction

 

The body has two ways to fight pathogens; lymphocytes, i.e. lymphocytes, circulate in the blood destroying pathogens, or cells specialized in fighting diseases produce antibodies circulating in the blood, which can neutralize pathogens by their action. Sometimes the functioning of the immune system can be disrupted. It can be mild, in which case the systems only work overactively, and as a result, e.g. asthma, allergies or skin symptoms such as atopic dermatitis. A more serious disorder in the immune system causes autoimmune diseases. (1,2)

 

What is an autoimmune disease?

 

The background of an autoimmune disease is always a malfunction of the immune system that causes inflammation in the body. For some reason, the body’s defense mechanisms do not work as they should, and they no longer separate pathogens from the body’s own cells and tissues. Defense and protection systems turn against the body itself as an inflammatory reaction. (2)

Autoimmune disease is caused by low immunity, an external pathogen, and in some cases also a hereditary factor. (1) According to the current understanding, there is no preventive treatment, but immunity can be strengthened by many means.

Joint pain is a common symptom of autoimmune disease.

Rheumatoid arthritis is a very common autoimmune disease in which the structures of the small joints have a continuous tissue-damaging inflammatory state. Other common autoimmune diseases include celiac disease, various allergies, asthma, psoriasis and thyroid disorders.

There is a long list of autoimmune diseases

 

More than 100 different forms of autoimmune diseases are known. All of them have in common the difficulty of being medicated and a large number of questions. Although there is a theory about how autoimmune diseases break out, their origin is still largely a mystery. The most common autoimmune diseases are thyroid dysfunction and rheumatoid arthritis. Asthma, allergies, celiac disease, chronic fatigue syndrome and psoriasis are also diseases classified as autoimmune. Rarer autoimmune diseases include e.g. adrenal gland dysfunction and myasthenia gravis causing muscle weakness. MS disease is also classified as an autoimmune disease and due to CBD oil’s effect on it, can read here.

 

Autoimmune rashes

 

Eczema and skin diseases that can be classified as autoimmune diseases include e.g. red lichen, vitiligo affecting the skin’s pigmentation and erythema multiforme with many symptoms. Many autoimmune diseases have several different symptoms. Rashes and skin symptoms are not associated with all diseases, but in some they are a significant factor. Psoriasis is a well-known skin-related disease based on immune defense. The symptoms of autoimmune diseases that appear as a rash may be relieved by CBD oil, and from that possible effect, you can read more here.

 

Endocannabinoid system behind immune defense

 

The endocannabinoid system is also part of the function of the immune response. It has an effect on the background of all body systems and, balancing, regulates the body’s immune defenses. The endocannabinoid system has been found to be present in some way in all cells of the body and their functions, including cells of the immune system. It also plays an important role in communication between these cells. (3,4,5)

Endocannabinoids activate the immune response

 

With endocannabinoids AEA (anandamide) and 2-AG (2-arachidonoylglycerol) have many important functions in the functioning of the immune system and can be considered effective immunomodulators. They e.g. both activate and inhibit immune system function and inhibit cytokines that cause inflammation. (5) Cells of the immune system have been found to have cannabinoid transport and degradation mechanisms and express both cannabinoid receptors (CB1 and CB2).

Red blood cells and chronic inflammation due to autoimmune disease.

Autoimmune disease involves inflammation in the body, which CBD can help with. CBD has an anti-inflammatory effect.

 

The CB2 receptor prevents inflammation

 

The primary location of the CB2 receptor in the body is the organs and tissues responsible for immunity. CB2 receptors are found in the cells of the immune systems approx. 100 times more than the CB1 receptor and that makes the endocannabinoid system a significant research target in the treatment of autoimmune diseases (5). The CB2 receptor is activated in the immune system and it has been noticed e.g. as an anti-inflammatory in various diseases such as inflammatory pain and liver infections. When activated, CB2 receptors also regulate the migration of immune cells in the body and their number increases during inflammatory pain (6)

 

The well-being of the immune system

 

Strong immunity is a basic pillar of health. The good immunity acquired as a child is the basis throughout life, but it can also be strengthened in adulthood. Immunity can be weakened, for example, due to stress, antibiotic courses or chronic illness. Also smoking, heavy alcohol use, lack of vitamins, etc. decrease the body’s ability to resist external pathogens. It is known that in addition to a healthy lifestyle, the immune response is also positively affected by the well-being of the mind.

Twice Nobel laureate Dr. Linus Pauling has said:

“You can trace every sickness, every disease, and every ailment to a mineral deficiency.”

A lack of micronutrients can weaken the normal function and effect of enzymes and vitamins in the body. A lack of vitamins can be avoided with well-absorbed supplements such as capsules containing humic and fulvic acid, which promote the normal functioning of the immune system (vitamin C, iron, copper and selenium). Humic substances enhance the absorption of minerals and thus help increase energy production and support immunity. You can order humus capsules from Hamppumaa’s online store.

 

CBD oil for autoimmune diseases

 

People with autoimmune diseases often use immunosuppressive treatments, i.e. treatments that lower immunity, because the immune system is overactive and needs to be calmed down.

CBD has been found in studies to be both immunosuppressive and anti-inflammatory. These properties are significant when considering the treatment of autoimmune diseases, as CBD can both slow down and stop an overactive immune system.

All autoimmune diseases differ from each other, which means that the guilty cells are also individual in each form of the disease. The contribution of endocannabinoids and the endocannabinoid system to immunity and autoimmune diseases is so significant that one could develop their own cannabinoid preparations for the diseases according to the purpose. While waiting for them, CBD oil might be of great help.

 

CBD oil dropper bottle and hemp plant in the background.

CBD has significant properties for the treatment of autoimmune diseases. CBD can slow down an overactive immune system.

 

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CBG (cannabigerol)

CBG or cannabigerol is a phytocannabinoid that has an anti-inflammatory or inflammation-reducing effect. It affects the function of immune cells and their neurotransmitters. CBG also acts as an anandamide reuptake inhibitor. (6).

 

Effect of terpenes

Terpenes are one of the less talked compounds in hemp. Terpenes are part of the therapeutic effect of hemp and they are involved in full-spectrum CBD oil. Carophyllenes have been found e.g. antimicrobial, antioxidant and anti-inflammatory. 46D-limonene can be anti-inflammatory and Gamma-terpinene has an effect on cytokine activity. (6)

 

Finally

Autoimmune diseases are common, but despite all the research, still largely unknown. It is very possible that in the future, effective specific drugs from cannabinoids will be developed for autoimmune diseases.

 

Sources

 

  1. Anttila V-J.. 2021. Duodecim. Elimistön Vastustuskyky. https://www.terveyskirjasto.fi/dlk01150. Referred to 5.6.2022.
  2. Mustajoki P.. 2018. Duodecim. Autoimmuunisairaudet. https://www.terveyskirjasto.fi/dlk00010. Referred to 5.6.2022
  3. Nichols J. ja Kaplan B.. Immune responses regulated by cannabidiol. https://pubmed.ncbi.nlm.nih.gov/?term=Kaplan%20BL%5BAuthor%5D. Referred to 5.6.2022.
  4. Almogi-Hazan O., Reuven O.. Cannabis, the endocannabinoidsystem and immunity – the journey from the Bedside to the bench and back. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352399/. Referred to 5.6.2022.
  5. Pandey R., Mousawy K., Nagarkatti M., Nagarkatti P.. 2009. Endocannabinoids and immune regulation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044336/. Referred to 5.6.2022.
  6. Giorgi V., Marotto D., Batticciotto A., Atzeni F., Bongiovanni S., Sarzi-Puttini P.. 2021. Cannabis and autoimmunity : Possible mechanisms of action. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313508/. Referred to 5.6.2022
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