The effect of CBD on well-being

The effect of CBD on well-being

CBD’s effect on well-being is versatile. On this page you will find studies on the effects of cannabinoids such as CBD, e.g. for the treatment of depression, anxiety, stress, insomnia and pain conditions.

During the past decades, a significant amount of research has been done on the effects of different cannabinoids. In particular, CBD has been extensively studied using various tests and methods. Several studies have taken into account the relationships of cannabinoids to each other, as well as their effect together and separately. However, research is still in its early stages and it is generally known that the factors affecting the endocannabinoid system are not yet fully understood. However, it has been shown to be true that external cannabinoids can be useful for a wide range of imbalances in the body, both in humans and in other mammals.

Depression

It seems that the endocannabinoid system is involved in the treatment of depression , although its role is not yet fully understood. Based on the published data, the endocannabinoid system provides new ideas and options in the treatment of depression, but further studies are still needed to determine which patient group could benefit from such treatment (1).

A 2018 study published in the journal Molecular Neurobiology concluded that CBD is a promising fast-acting antidepressant. While traditional antidepressants typically take some time to work, a study in rodents showed that CBD had rapid and sustained antidepressant-like effects (2).

There are many individual cases in the world where cannabis has helped research patients in the treatment of depression. In addition, new studies have been conducted that report the importance of the role of the endocannabinoid system in depression, indicating that there is a link between endocannabinoid dysfunction and depression. The TGA (Therapeutic Goods Administration ) is known to approve cannabis for patients with depression, which suggests that cannabis plays a role in the treatment of depression (3).

We still lack high-quality clinical studies that emphasize depression or the improvement of depression as the most important outcome. However, there are mouse experiments that show that cannabis can help with depression. Other studies, such as the Sativex studies, have shown a significant improvement in the well-being of people using cannabis medicines (4).

The anti-depressant effects of cannabis, as well as the interaction between antidepressants and the endocannabinoid system, were reported in a study in 2010. The study in question was conducted to evaluate the antidepressant-like effects of delta9-THC and other cannabinoids. The results of the study show that delta9-THC and other cannabinoids have an antidepressant-like effect and can therefore influence the mood-enhancing properties of cannabis (4).

Anxiety

Studies that were conducted on animals and performed various tests such as the forced swim test (FST), Elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD has anti-anxiety and anti-depressant effects in research animals (5).

Overall, the existing preclinical evidence strongly supports the potential of CBD in the treatment of anxiety disorders. CBD has multifaceted effects that are relevant in several different areas related to anxiety (6).

Since endocannabinoids appear to play an important role in major depression, generalized anxiety disorder, and bipolar disorder, the Cannabis sativa plant is suggested for their treatment. The endocannabinoid system covers a wide range of the entire body, including the brain, and is responsible for a wide range of different body functions. The system in question is linked to mood and related disorders. Exogenous cannabinoids can alter its activity. CB1 and CB2 receptors mainly act as binding sites for endocannabinoids and phytocannabinoids produced by cannabis flowers. However, cannabis is not a single compound, but is known for its complex molecular profile, which produces numerous phytocannabinoids and many different terpenes. Thus, synergism has a positive effect due to the addition of terpenes to cannabinoids (7).

Read more in the article CBD oil can relieve anxiety .

Stress

A study published in 2018 found that CBD has stress-reducing effects that can reduce stress-related depression. The results of the study suggest that in chronically stressed mice, CBD prevents stress-induced reduced hippocampal neurogenesis and stress-induced angiogenesis, i.e. new blood vessel formation (8). Read more in the article CBD and stress .

Nerve pain

According to the study, cannabidiol (CBD), the significant non-psychoactive component of cannabis, has anti-inflammatory and immunomodulatory effects. This study investigated its therapeutic potential in the treatment of neuropathic and inflammatory pain in rats. The results of the study show that CBD has potential for therapeutic use in painful chronic pain conditions (9).

Pain

A 2018 review , Cannabinoids and Pain: New Insights From Old Molecules , evaluates how well CBD works for chronic pain relief . The review looked at studies conducted between 1975 and March 2018. These studies looked at a variety of pain conditions, including cancer pain, neuropathic pain, and fibromyalgia. Based on these studies, researchers concluded that CBD was effective in general pain management and did not cause negative side effects (10).

Inflammations

One 2017 review found that CBD’s anti-inflammatory properties may help with the following conditions (11):

A 2016 study looked at the effect of CBD on rats with arthritis . Researchers found that topical CBD gel reduced joint swelling and pain in rats. No significant side effects resulted from the experiment. Research shows that CBD cosmetics have therapeutic potential for reducing the behavior and inflammation associated with arthritis pain without apparent side effects (12).

Insomnia

Several studies on CBD, anxiety and sleep have found that many patients do not notice a difference immediately. A 2019 study found that subjects took about a month to notice a difference (13). So be patient and remember that the desired results may take time.

The final sample consisted of 72 adults with primary concerns of anxiety (n = 47) or poor sleep (n = 25). Anxiety scores decreased during the first month in 57 patients (79.2%) and remained low during the duration of the study. Sleep quality improved during the first month in 48 patients (66.7%), but varied over time. In this chart review, CBD was well tolerated in all but three patients (13).

CBD may also be promising for those suffering from REM sleep disorders and excessive daytime sleepiness. The synthetic cannabinoid nabilone can reduce PTSD-related nightmares and improve sleep among patients with chronic pain (14).

Read more in the article CBD oil and insomnia .

Effects of CBD on concentration

CBD has several properties that not only improve our general well-being, but also increase concentration and energy. It stimulates the endocannabinoid system, one of whose functions is to regulate attention, memory, concentration and energy. By helping the endocannabinoid system to function better, CBD also helps increase our productivity (15).

If your inattention and inability to concentrate are due to health issues, we strongly recommend that you consult your doctor for diagnosis and treatment. While CBD can help improve concentration, focus, and energy, it is still necessary to find the root cause of your problems in order to properly address it. Your doctor can also help you find the best CBD products for focus or energy and dosage.

Terpenes in the treatment of depression, anxiety and stress

Terpenes found in hemp and their effect on anxiety, depression and stress have also been the subject of research. Terpenes are found especially in the essential oils of hemp, but also in the resin of plants. Terpenes give hemp its characteristic aroma. Listed below are 4 common terpenes and their effects. Note most of the experiments have been done on mice and further studies are needed.

  • Limonene – research shows that the terpene limonene can relieve stress and anxiety (16).
  • Pinene – research shows that the terpene pinene has anti-anxiety effects (17).
  • Linalool – research shows that the smell of linalool can have anxiolytic effects (18).
  • Myrcene – research shows that myrcene has a calming effect (19).

Possible side effects of CBD

Although many studies show that CBD is generally safe, it is worth considering the fact that people are different and that different active ingredients will cause a different reaction in some people than in others. Here you can find information about the possible side effects that CBD may cause in some rare cases.

Side effects are relatively rare. However, some users may experience possible minor side effects such as Below is a list of side effects that have been obtained in the 2019 study’s mouse experiments (20).

  • Fatigue
  • Diarrhea
  • Change in appetite
  • Weight fluctuation
  • Mood swings
  • Possible interactions with medicines can reduce or strengthen the effect of the medicine.

The text on this page is not intended for product marketing. The website administrator is also not responsible for the correctness of the text and possible errors. The reader should carefully check all the sources appearing in the text. The content of the page is not intended as self-care instructions for any disease or situation. We recommend discussing possible changes in your life situation first together with an expert doctor.

Sources

  1. Ewa Poleszak et al. Cannabinoids in depressive disorders , Life Sciences, Volume 213, 2018
    https://www.sciencedirect.com/science/article/abs/pii/S0024320518306040
  2. Sales AJ, Fogaça MV, Sartim AG, et al. Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNF signaling and synaptogenesis in the prefrontal cortex . Mol Neurobiol 56, 1070–1081 (2019). doi:10.1007/s12035-018-1143-4
  3. Wen-Juan Huang et al. Endocannabinoid system: Role in depression, reward and pain control , Mol Med Rep. 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042796/
  4. Abir T. El-Alfy et al. Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L . Pharmacology Biochemistry and Behavior. Volume 95, Issue 4, 2010. https://www.sciencedirect.com/science/article/abs/pii/S0091305710000730
  5. Alexandre R de Mello Schier et al. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa . CNS Neurol Disord Drug Targets, 2014. https://pubmed.ncbi.nlm.nih.gov/24923339/
  6. Esther M. Blessing et al. Cannabidiol as a Potential Treatment for Anxiety Disorders . Neurotherapeutics. 2015. https://link.springer.com/article/10.1007/s13311-015-0387-1?handl_url
  7. Ferber, Sari G. et al. The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders . Current Neuropharmacology, Volume 18. Number 2. 2020. https://www.ingentaconnect.com/contentone/ben/cn/2020/00000018/00000002/art00004
  8. José A. Crippa et al. Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age . Front Immunol. 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161644/
  9. Barbara Costa et al. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain . Eur J Pharmacol. 2007. https://pubmed.ncbi.nlm.nih.gov/17157290/
  10. Sonja Vučković et al. Cannabinoids and Pain: New Insights From Old Molecules . Front Pharmacol. 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277878/
  11. Simona Pisanti. Cannabidiol: State of the art and new challenges for Therapeutic applications . Pharmacol Ther. 2017. https://pubmed.ncbi.nlm.nih.gov/28232276/
  12. DC Hammell et al. Transdermal cannabidiol reduces inflammation and pain-related behaviors in a rat model of arthritis . Eur J Pain. 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/
  13. Scott Shannon et al. Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J. 2019. https://www.healthline.com/health/cbd-for-insomnia#how-to-use
  14. Kimberly A. Babson. Cannabis, Cannabinoids, and Sleep: a Review of the Literature . Current Psychiatry Reports. volume 19, Article number: 23. 2017. https://link.springer.com/article/10.1007%2Fs11920-017-0775-9
  15. Ruth E Cooper. Cannabinoids in attention-deficit/hyperactivity disorder: A randomized-controlled trial. Eur Neuropsychopharmacol. 2017. https://pubmed.ncbi.nlm.nih.gov/28576350/
  16. Naiana GPB Lima et al. A nxiolytic-like activity and GC-MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants. Pharmacol Biochem Behav. 2013. https://pubmed.ncbi.nlm.nih.gov/22995322/
  17. Tadaaki Satou et al. Daily inhalation of α-pinene in mice: effects on behavior and organ accumulation. Phytother Res. 2014. https://pubmed.ncbi.nlm.nih.gov/25340185/
  18. Hiroki Harada et al. Linalool Odor-Induced Anxiolytic Effects in Mice. Front Behav Neurosci. 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206409/
  19. T Gurgel do Vale et al. Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia Alba (Mill.) ne Brown. Phytomedicine. 2002. https://pubmed.ncbi.nlm.nih.gov/12587690/
  20. Ewing Le, Skinner Cm, Quick Cm, et al. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules. 2019; 24. https://www.mdpi.com/1420-3049/24/9/1694

Fatty liver and CBD

Fatty liver and CBD

Fatty liver, a disease that regularly appears in the headlines of the tabloids, is a real threat to public health and, according to estimates, up to a quarter of Finnish adults suffer from it. It is completely possible to cure fatty liver and in this article we will get to know whether CBD oil could be of any help to restore the situation to its original state. We also look at the functions of the endocannabinoid system in the background of fatty liver and find out what fatty liver actually is!

 

What is fatty liver?

 

Fatty liver is the most common liver disease and occurs especially in the so-called in welfare states. Before, it was diagnosed only in 40-60 year olds and mostly alcoholics, but as overweight becomes more common, it is found in more and younger people, and the cause is no longer alcohol but an unhealthy diet. (1,2)

According to estimates, even one in four Finnish adults has a fatty liver. Fatty liver cases caused by alcohol are only a fraction of this, as approx. 75% percent of fatty liver diagnoses are given due to diet. Fatty liver is very common in diabetics, but it is often caused by factors that are not so easy to influence (1).

In fatty liver, too much fat accumulates inside the liver cells, in the fat cells and in the abdominal cavity. This excess fat is caused by extensive metabolic disorders, the causes of which are diverse and individual. (1,2)

 

Causes of fatty liver

 

Fatty liver is mainly caused by unhealthy lifestyles. Heavy alcohol use and being overweight are the most significant factors, but it’s not always about that, but sometimes genes also predispose the liver to obesity. Very rarely, but sometimes, some medicines can cause fatty liver.

In addition to lifestyle, age and insulin resistance also affect fatty liver. Insulin resistance is a state of the body that contributes to the onset of various diseases, you can read more about it e.g. from here .

 

Symptoms of fatty liver

 

Fatty liver in itself does not cause any clear tangible or visible symptoms, but it contributes to various diseases such as diabetes and onset of hypertension. (1)

Fatty liver diagnosis at the doctor's office.

Fatty liver increases the risk of developing hypertension.

 

Diagnosis

 

Fatty liver is not associated with pain or other sensations, so it can be challenging to detect it before it’s too late. Although the clear indications of the possibility of fatty liver are usually heavy alcohol use and obesity, overweight or alcohol problems do not always occur, and the liver values may also be within the reference values despite the disease.

The diagnosis is confirmed by a blood test and an echocardiography of the liver.

 

Prevention and treatment of fatty liver

 

Healthy lifestyles are the basis of both the prevention and treatment of fatty liver.

There is no medical treatment directly available for fatty liver, but with a lifestyle overhaul, a fatty liver can usually be cured completely.

The most effective way to treat fatty liver is to reduce alcohol consumption and get rid of excess weight. It has been established that even a few percent weight loss can reduce the fat percentage of the liver by up to ten. Reducing alcohol, regular exercise and an optimal diet together is the most effective and fastest way to get rid of fatty liver, but investing in any of them is already a step in the better direction! (1)

You should add fruits, vegetables and berries to your diet instead of slow carbohydrates and use a wider range of different fat sources.

There are many perspectives on the choice of fats, but a general guideline could be to pay attention to versatility and quality. Many foods already contain a lot of fat, such as meat, eggs, avocado, nuts, etc. and there is always no need for additional fat (bread topping, frying fat, etc.) in the meal.

Sugar and hidden sugar should also be avoided in large quantities, especially when treating fatty liver. You should pay attention to the package leaflets, because even yogurts can contain huge amounts of sugar. More than half of regular white sugar contains fructose, which promotes fatty liver.

Fatty liver has long been considered a benign disease that can be completely cured, but if it is not treated in time, it can progress to inflammation, fibrosis or even liver cirrhosis. A scarred liver can no longer be healed, and in Finland the mortality from liver cirrhosis is at the top level in Europe.

 

The endocannabinoid system in the background of fatty liver

 

The endocannabinoid system that maintains the body’s balance is found in all mammals and it monitors all the processes going on in the body. Appetite and weight control have both been regulated by the endocannabinoid system for a long time. Behind these seemingly simple functions are numerous processes and events, which, roughly speaking, all functioning endocannabinoid Thanks to the CB1 receptor activated by 2-AG .

Liver cells have been shown to produce both known cannabinoids , anandamide and 2-AG, to be produced and the liver is self-sufficient in terms of them. According to animal experiments, 2-AG levels in the liver increase due to alcohol, and anadamide levels increase with fatty food. Both anandamide and 2-AG have been shown to have anti-scarring effects. (3,4,5)

Of the cannabinoid receptors, only CB1 is expressed in a healthy liver. In cases caused by both alcohol and fatty food, increased CB1 receptor levels have been noted, but the CB2 receptor appears in the liver only when the liver has cirrhosis. (5)

 

CBD oil and hemp leaf. For treating fatty liver.

CBD oil may prevent the development of fatty liver by affecting the accumulation of lipids in the tissues.

 

CBD oil for fatty liver

 

The use of the CBD oil the effect on fatty liver has been studied quite a bit as such, but CBD’s anti-inflammatory effects, as well as its antioxidant properties, are properties that may lead to some relief. As fatty liver is a completely curable disease, its primary and most important treatment is definitely reducing alcohol consumption and reducing body weight through diet and exercise, depending on which is the problem in the first place.

CBDhas been found to have an effect on preventing diet-induced liver damage by reducing the accumulation of lipids in tissues. CBD also reduces the activation of inflammation and the presence of inflammatory cytokines (6).

CBD also has antioxidant properties that have been shown to alleviate oxidative stress. Alcohol and high-fat food increase the production of reactive oxygen species and CBDThe antioxidant properties of (6)

 

Finally

Fatty liver is a very common disease that can be cured if it is detected early enough. Depending on the genes, it is very easy to take care of the health of the liver, because the basis of its well-being is mostly healthy lifestyles.

The endocannabinoid system has its own roles in the liver and also in the background of liver health and has been found to be completely self-sufficient in terms of endocannabinoid production. The use of CBD oil to support the treatment of fatty liver is still quite a gray area, but probably in the future, research will be focused on the utilization of cannabinoids due to their versatile therapeutic effects.

 

Attachments

 

  1. Mustajoki P.. 2021. Health Library Duodecim. Fatty liver. https://www.terveyskirjasto.fi/dlk00070. Referred on 11/14/2022.
  2. Mervaala E., Tarnanen K. and Yki-järvinen H.. 2020. Fatty liver disease (Non-alcoholic fatty liver disease). https://www.kaypahoito.fi/khp00132. Referred on 11/14/2022.
  3. Purohit V., Rapaka R. and Shurtleff D.. 2010. Role of Cannabinoids in the Development of Fatty Liver (Steatosis). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844512/. Referred on 11/14/2022
  4. Alswat KD. 2010. The Role of Endocannabinoids System in Fatty Liver Disease and Therapeutic Potentials. https://pubmed.ncbi.nlm.nih.gov/?term=Alswat%20KA%5BAuthor%5D. Referred on 11/14/2022.
  5. Tam J., Liu J., Mukhopadhyay S., Cinar R., Godlewski G. and Kunos G.. 2011. Endocannabinoids in Liver Disease. https://pubmed.ncbi.nlm.nih.gov/?term=Jan %20J% 5BAuthor%5D. Referred on 11/14/2022.
  6. Jiang X., Gu Y., Huang Y., Zhou Y., Pang N., Luo J., Tang Z., Zhang Z., and Yang L.. 2021. Frontiers of pharmacology. CBD Alleviates Liver Injuries in Alcoholics With a High-Fat High-Cholesterol Diet Through Regulating the NLRP3 Inflammasome–Pyroptosis Pathway. https://www.frontiersin.org/articles/10.3389/fphar.2021.724747/full. Referred on 11/14/2022.
Does CBD soothe restless legs?

Does CBD soothe restless legs?

Every tenth person in the world suffers from the symptoms of restless legs either regularly or occasionally. It is a disease affecting the quality of sleep and mood for which there is no curative treatment. In this article, we’ll find out what restless legs are and whether you could CBD oil calms them down!

 

Restless legs

 

Restless legs syndrome (RLS) is classified as a neurological, sensorimotor disease that has only become more common in recent decades. Often, when making a diagnosis, it turns out that people who suffer from restless legs have had symptoms since childhood, and there is usually a genetic link to the disease. (1) The name of the disease, restless legs, is incorrect in the sense that the symptoms are not necessarily limited to the legs, but there are often sensations in the arms as well.

 

Symptoms of restless legs

 

The symptoms manifest as a strong need to move the limbs, especially the legs. The sensations are obviously difficult to describe, but we are talking about pressure, tingling, burning, itching and an unpleasant feeling deep inside the leg. The symptoms start in the evenings before going to bed and for some even when they sit down to calm down at the end of the day. You might think that restless legs need rest and peace, but it seems that the right amount of exercise eases the symptoms or even stops them temporarily. Lightly moving your legs when the symptoms start may relieve them and make you feel easier enough to catch up on sleep. (1,2,3)

A woman is lying on the grass and swinging her restless legs.

The symptoms of restless legs often occur at night and in the evenings when the legs are at rest. Restlessness in the legs may force you to get up and swing your legs, even if the person is otherwise tired and ready to sleep.

Anxiety, which occurs as a side effect, is relieved by CBD oil

 

Restless legs may cause side effects of insomnia and daytime fatigue after a bad night’s sleep. The need to move and the strong compulsion in the legs wakes up throughout the night and sometimes requires even getting out of bed. (1,2) Anxiety and stress are also commonly mentioned side symptoms. For anxiety relief with CBD oil can read here and about the effect of CBD oil on stress here. CBD oil is versatile in its care, and its effects that support the body’s functions also help restless legs, at least indirectly. CBD oil may also help with sleep-related challenges and you can read more about it here .

 

Reasons behind restless legs

 

The origin of restless legs is not completely known, but in addition to hereditary factors, iron deficiency anemia and a disturbance in dopamine production contribute to the onset (1,3). Lack of exercise, coffee, tobacco, alcohol and some medications may also increase and maintain symptoms (1).

 

Iron deficiency underlying the symptoms

 

According to studies, iron deficiency in the substantia nigra of the brain is behind restless legs (3). The iron content of the blood does not yet tell whether there is enough iron in the tissues and the brain, and it has been found that iron deficiency occurring in the substantia nigra of the brain can cause symptoms of restless legs.

Disturbance in dopamine production

 

The neurotransmitter hormone dopamine is involved in many things and is also involved in body movements. Its lack causes e.g. dystonia, i.e. involuntary movement of the body.

Dopamine levels in the nervous system naturally decrease towards evening, and are at their lowest at night. Dopamine’s involvement in the production of body movement and its natural production rhythm is directly related to when restless legs begin to show symptoms.

Studies have found an increase in dopamine production related to restless legs and this is interpreted as a disturbance in dopamine production. An increase in production can be a sign of bad signaling in the brain, and despite the overproduction, the effect of dopamine weakens for certain brain cells at certain times of the day more than usual.

Dopamine is produced by the substantia nigra of the brain, and it is the lack of iron in the dopamine cells in people suffering from restless legs that supports the theory of the combined effect of a dopamine disorder and iron deficiency in the emergence of the syndrome. It is still unclear how there can be too little iron in the brain when iron levels in the blood are normal. (3)

 

Restless legs during pregnancy

 

During pregnancy, a woman’s body adapts to work in more cramped conditions than normal. In addition to the nerve pathways being pinched and the blood vessels constricted, the legs are suddenly subjected to more weight than they are used to carrying. Symptoms of restless legs during pregnancy are 3 times more common than in the general population, and they usually stop soon after pregnancy. The risk of getting restless legs during pregnancy is increased by being overweight and the age of the expectant mother. (4)

 

Restless legs syndrome treatment

 

In the absence of a working form of treatment, the treatment for restless legs currently consists of small pieces that each person with symptoms assembles according to their needs. Sufficient exercise helps most people as long as it is not too late in the evening. You should also avoid consuming caffeine, alcohol and tobacco too close to bedtime. Restless legs strongly affect the quality of sleep for most people, so you should take care of suitable conditions for sleeping, such as a good bed, suitable temperature and relaxation before settling down to sleep.

 

Magnesium and other minerals relieve symptoms

 

Restless legs are also treated by taking care of iron reserves and iron absorption. It would be important to get the iron levels of the tissues and brain to a good level, and therefore it is also essential to consider other minerals that affect the absorption and transport of iron to the right places. Especially copper and magnesium are important minerals for the absorption of iron, and their adequate intake should be taken care of in a varied diet and possibly also in the form of a supplement. Well-absorbed iron and other minerals to support the body are e.g. in humic and fulvic acid capsules which can be found here .

 

Restless legs on the pier relax thanks to CBD oil.

CBD can help with the symptoms of restless legs, because CBD affects nerve function by optimizing and balancing it as needed.

 

CBD oil to soothe symptoms?

 

The effectiveness of CBD oil in people with restless legs syndrome may be based on CBD ‘s ability to prevent excessive dopamine release by restoring nerve activity to a more normal state (5).

CBD oil has been shown to be an effective aid in the treatment of various neurological diseases such as epilepsy and MS . The relief of the symptoms of Parkinson’s disease with CBD oil has also been studied with good results, as well as fibromyalgia. All of these diseases, with the exception of fibromyalgia, have the same involuntary, life-affecting movements of the body and precisely these symptoms CBD oil has been found to bring relief or even release.

You can read more about alleviating the symptoms of epilepsy with CBD oil here. Also for the treatment of MS There is an article written on CBD , which you can read here. Restless legs associated with fibromyalgia are very common and due to the effect of CBD on fibromyalgia can read here .

The treatment of restless legs with CBD oil has been studied unfortunately little, but the few studies and the numerous experiences of users give good promises of a positive treatment response. A study of six participants was conducted in France, of which 5/6 stated that they had received help for restless legs (6) and in connection with a study in Canada, it was found that more than half of the participants who had restless legs as one of the symptoms received CBD oil helps with symptoms (7).

 

CBD foot cream

 

Although there is no direct cure for restless legs, you can try a 100% natural CBD foot cream specially designed for tired legs to treat its symptoms, which includes several active substances. CBD foot cream reduces swelling, warms and relaxes the feet. At the same time, it also stimulates peripheral blood circulation and makes the legs feel fresh and light. The product does not contain parabens, artificial colors, flavors or preservatives CBD foot cream can be ordered Hemp from the online store .

 

In summary

Restless legs is a disease that occurs either by itself or along with another disease. Treating it with CBD oil has not been studied yet, but since the endocannabinoid system is so important behind the body’s functions, it is possible that cannabis-based medicines will still be developed, also for restless legs.

 

Sources

 

  1. Saarelma O.. 2022. Duodecim health library. Restless legs syndrome. https://www.terveyskirjasto.fi/dlk00294. Referred to on 30/06/2022.
  2. Partinen M.. 2006. Duodecim periodical book. Restless legs. https://www.duodecimlehti.fi/duo96142. Referred to on 30/06/2022.
  3. Johns Hopkins Medicine. Causes of restless legs syndrome. https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/causes.html. Referred to on 30/06/2022.
  4. Jansson M.. 2017. Patient’s medical journal. Restless legs are monitored during pregnancy. https://www.potileanlaakarilehti.fi/uutiset/levottomat-jalat-valvottavat-raskausaikana/. Referred to on 30/06/2022.
  5. Wenk G.. 2020. Psychology today. Cannabis for restless legs syndrome. https://www.psychologytoday.com/intl/blog/your-brain-food/202007/cannabis-restless-leg-syndrome. Referred to on 30/06/2022.
  6. Megelin T. and Ghorayeb I.. 2020. More evidence of cannabis efficacy in restless legs syndrome. https://pubmed.ncbi.nlm.nih.gov/31820197/. Referred to on 30/06/2022.
  7. Samaha D., Kandiah T. and Zimmermann D.. 2020. Cannabis Use for Restless Legs Syndrome and Uremic Pruritus in patients treated with maintenance dialysis: A Survey. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488602/. Referred to on 30/06/2022.
Alzheimer’s disease and CBD

Alzheimer’s disease and CBD

Alzheimer’s disease is a memory disease that has a strong impact on life, for which a curative treatment has not yet been invented. In this article, we will learn about Alzheimer’s disease, the endocannabinoid system behind it, and also whether CBD oil could help in its treatment or symptom management.

Alzheimer’s disease is a memory disorder

 

Alzheimer’s, a degenerative memory disease of the brain, is a disease of the older population, which is rapidly becoming more common and occurring in younger and younger people. It usually affects people over 80 years old, but today we see Alzheimer’s patients 60+ years old. In Finland, approx. 70,000 people and it is slightly more common in women than in men. Life expectancy is hopeful, as it can be up to 20 years from the onset of the disease.

Aloi Alzheimer, a doctor and researcher who lived in the 19th century, became interested in the pathology of the brain and wanted to find out the identification and characterization of the diseases behind clinical syndromes. He observed the first observations of brain degeneration at the very end of the 19th century, and this was the first step both in identifying Alzheimer’s and in acknowledging its existence. (1)

 

Memory disorders

 

Alzheimer’s belongs to the family of memory diseases. The most common are Alzheimer’s, vascular memory disease, Lewy body disease and memory diseases caused by degeneration of the frontotemporal lobe. Dementia is a syndrome in which there is at least one additional symptom in addition to the memory disorder, such as language weakness or impaired dexterity. (2)

 

Alzheimer’s causes

 

The root cause of the disease is not known. Small changes occur in the brain that damage nerve pathways and brain cells. The brain is affected by the accumulation of protein deposits (amyloid) and tau protein, as a result of which memory and information processing deteriorate. (3, 4)

In the background, there are also various risk factors and elements that promote the onset of the disease. Oxidative stress, excessive breakdown of the neurotransmitter acetylcholine, brain injury, heavy metals accumulating in the body and brain are not the only culprits, but contribute to the onset of the disease.

Basically, it is brain degeneration due to the death of nerve and brain cells.

 

Is Alzheimer’s hereditary?

 

Alzheimer’s is partly hereditary, as it is caused by genes, but its onset is not dependent on them. Genes have the greatest influence on the development of Alzheimer’s disease apolipoprotein E allele e4, but the disease seems to be more common in some families, even if not everyone has the gene in question. (3)

 

An old man suffering from Alzheimer's disease recalls photographs.

The symptoms of Alzheimer’s disease are related to memory and difficulties in recognizing things.

 

Alzheimer’s symptoms

 

The symptoms of Alzheimer’s are similar for all sufferers, but there are also differences depending on the quality of the disease. Sometimes the symptoms focus on vision-related symptoms, such as recognizing things, etc. and sometimes more for memory loss.

Usually, the first clear symptom is a marked decline in memory. At first it may seem like a distraction, but as time goes on, challenges start to appear even in complex activities, such as traveling or managing money. (3)

A natural part of getting older is that you no longer remember everything the same way you did when you were younger. In Alzheimer’s disease, short-term memory weakens and learning new things becomes difficult earlier than average.

The symptoms also include psychological symptoms. Many people with Alzheimer’s can be aggressive and quick-tempered, as well as direct and rude in their words. The symptoms are not necessarily always continuous, but for a moment the functioning, memory and psyche can be as before the illness. (3)

 

Alzheimer’s diagnosis, medication and treatment

 

Alzheimer’s disease is usually diagnosed at an early stage because it is quite easy to recognize. The symptoms are quite clear, but structural images of the brain are usually taken in addition to neurological tests to make sure. Early diagnosis is also made possible by samples taken from the spinal fluid. (3)

Alzheimer’s disease is treated with drugs that aim to increase concentration, reduce psychological symptoms and improve functional capacity. At least for the time being, there is no drug that cures or stops the disease, instead medical treatment focuses on alleviating the symptoms and slowing down the progression of the disease. (5)

The neurotransmitter acetylcholine is central to neurodegeneration. It transmits messages between neurons and plays a significant role in memory formation and information retrieval within the brain. People with Alzheimer’s have been found to have lower levels of this neurotransmitter compared to healthy brains, and for this reason, drugs that prevent the breakdown of acetylcholine and improve its function have been developed especially for the treatment of Alzheimer’s disease. (3,4,5)

 

Risk factors and prevention

 

Alzheimer’s disease has several risk factors. i.a Lack of mental and physical challenge, alcohol, loneliness, and low educational background, as well as high blood pressure and cholesterol, insulin resistance, brain injuries, and brain-related circulatory disorders can contribute to the onset of Alzheimer’s.

Prevention is very much related to following a healthy lifestyle.

Today, there is a lot of discussion about the impact of the environment on health, from the cleanliness of food to air pollution. Heavy metals have been studied as particles that accumulate in the body and have negative effects, e.g. to the nervous system and skeleton. Avoiding them completely is almost impossible, but with some small actions in everyday life there is a chance to influence this. (6,7,8)

Heavy metals end up in the environment, i.e. food, water, soil and air, e.g. due to emissions from factories and cars, but also due to plant protection agents and chemicals used in water purification (6,7,8). Finnish tap water, food and air are clean compared to many other corners of the world, but this is no Lintukoto either. Cleanly produced food, a water filter in the tap and avoiding excess chemicals in cosmetics, household goods (e.g. plastic dishes) and detergents are ways that may reduce the risk of getting sick, e.g. to Alzheimer’s disease.

You should take care of your brain health. Their condition can be maintained with the help of a versatile clean diet and by giving them a suitable challenge even at the threshold of old age.

Endocannabinoid system underlying Alzheimer’s disease

 

The endocannabinoid system role in the background of Alzheimer’s has been studied to some extent. The system in question has been of interest to researchers for a long time, as its malfunctions seem to be the underlying cause of almost all diseases. The endocannabinoid system has been found in all the world’s mammal species, and improving its function is definitely one of the biggest goals of future drug development.

 

Cannabinoid receptors

 

The endocannabinoid system consists of the body’s own cannabinoid receptors, endogenous cannabinoids, and their disintegrating molecules.

There are two known cannabinoid receptors, CB1 and CB2 receptors, and it seems that in Alzheimer’s disease the CB2 receptor is especially abundant, close to hardened protein deposits in the brain (9). The CB1 receptor occurs more in the brain and the CB2 receptor in the tissues responsible for immunity. Although each receptor has its own tasks and places, both receptors can be found almost everywhere in the body.

The CB1 receptor in the brain is associated with e.g. memory, learning, behavior and appetite. (9,10)

 

Endocannabinoids

 

Endocannabinoids are cannabinoids produced by the body itself, and they have many different tasks behind the well-being of the body, some of which target e.g. to memory. Changes related to the breakdown and function of endocannabinoids have been observed in the brains of people with Alzheimer’s disease. FAAH is the endocannabinoid system’s own enzyme that breaks down endocannabinoids, which may start to form too much if the system is not working properly. As a result, e.g. endocannabinoid anandamide production weakens in nerve cells and the enzymes that cause inflammation are allowed to multiply. Anandamide levels are lower in Alzheimer’s patients compared to healthy people, but no differences have been observed in the levels of another known endocannabinoid, 2-AG. (9,10)

 

Elderly people suffering from memory loss play chess.

Oxidative stress is related to the onset of Alzheimer’s disease. CBD is an antioxidative cannabinoid that reduces symptoms caused by oxidative stress. CBD has also been found to have a memory-enhancing effect.

 

Does CBD oil help with Alzheimer’s?

 

Full spectrum CBD oil is an oil obtained from hemp, into which all the active substances of the plant have been pressed. There are almost 500 different active substances in hemp and 120 different cannabinoids. Hemp has been known in herbal medicine for thousands of years and has been used successfully for a long time for various ailments. A few compounds that are especially important for Alzheimer’s disease have been listed below.

CBD (cannabidiol)

 

Oxidative stress is one risk factor in the development of Alzheimer’s disease. CBD is an antioxidative cannabinoid that reduces symptoms caused by oxidative stress. CBD is also a cannabinoid that calms the nervous system, which has been found in animal experiments to improve recognition memory. Agitation and aggression may also calm down under the influence of CBD. (11,12)

According to some studies, CBD has been recommended for the treatment of Alzheimer’s at a daily dose of 300 mg, either increasing or decreasing it depending on how it starts to work. The benefit can be seen as an improvement in general well-being and a slowing down of the progression of the disease, which of course can be difficult to notice.

 

CBG (Cannabigerol)

 

The better known and more researched CBD has its own effects on the functions underlying Alzheimer’s, but other cannabinoids have also been found to have therapeutic effects. Also called the mother of all cannabinoids Cannabigerol ( CBG) has been found to protect nerves, relieve inflammation and improve motor deficits. (14)

Terpenes

 

Terpenes, which are mainly responsible for the aromatic properties of hemp, have been found to have therapeutic effects either alone or at least as part of CBD oil synergy. There are many different types of terpenes and some of them have an effect preventing the breakdown of acetylcholine. Some terpenes, like CBD, have the effect of reducing oxidative stress and have been found to increase blood flow to the brain. (11,13)

 

A person suffering from memory disease (Alzheimer) listening to music happily.

Listening to music familiar to the patient has been found to be an effective way to rehabilitate Alzheimer’s patients. Music evokes feelings and memories that activate the frontal lobe of the brain, which is the last place the disease wreaks havoc.

 

Music in the rehabilitation of Alzheimer’s disease

 

The effect of music on people with Alzheimer’s disease has been studied more widely in recent years. Based on the results, it seems that Alzheimer’s patients literally come alive when they hear familiar music from their past. Familiar music revives old memories and activates cognitive functions.

According to experts, there is a special place in the brain where memories of music are stored for a very long time. Based on the experience of many people, listening to familiar music is one of the most effective ways to rehabilitate Alzheimer’s patients.

Music evokes memories and emotions and activates the frontal lobe area of the brain, which is the last place where disease wreaks havoc on tissues. Singing can also be of similar benefit in Alzheimer’s rehabilitation. (15) According to studies, people suffering from memory disorders benefit best when they sing songs they already know together (16).

Summary

 

Alzheimer’s disease is a untoward, usually lifelong disease that affects the performance of everyday chores. Short-term memory weakens and learning new things becomes difficult, before long familiar people become strange and a person may get lost on the way to the convenience store. The endocannabinoid system has its own part in the functioning of the brain, and future drug treatment for Alzheimer’s disease might be related to, for example, blocking the endocannabinoids that break them down. CBD oil may have therapeutic effects, e.g. in functions related to improving memory, reducing aggression and protecting the nervous system and thus it could be a potential gentle aid to support the treatment of Alzheimer’s.

 

Sources

 

  1. Haltia M.. 2014. Period book Duodecim. Alois Alzheimer and his many diseases. https://www.duodecimlehti.fi/duo11990. Referred on 1/11/2022.
  2. Memory Union. Memory disorders. https://www.muistiliitto.fi/fi/muistisairaudet/muistihairiot-ja-sairaudet/muistisairaudet. Referred on 1/11/2022
  3. Juva K.. 2021. Health Library Duodecim. Alzheimers disease. https://www.terveyskirjasto.fi/dlk00699. Referred on 1/11/2022.
  4. Toivanen P.. 2014. University of Turku. Faculty of Medicine and Health Technology. Bachelor’s thesis. Protein accumulation in Alzheimer’s disease. https://trepo.tuni.fi/bitstream/handle/10024/117175/ToivanenPinja.pdf?sequence=2. Referred on 1/11/2022
  5. Rosenvall A., Hallikainen M. and Strandberg T.. 2018. Periodical Duodecim. Drug treatment of Alzheimer’s disease in different stages of the disease. https://www.duodecimlehti.fi/duo14668. Referred on 1/11/2022.
  6. Evira’s studies 2/2015. Evira. Risk assessment of Finnish children’s exposure to heavy metals in foodstuffs and household water. https://www.ruokavirasto.fi/globalassets/tietoa-meista/julkaisut/julkaisusarjat/tutkimukset/riskiraportit/riskinarviointi-suomalaisten-lasten-altistumisesta-elintarvikkeiden-ja-talousveden-raskasmetalleille.pdf. Referred on 1/11/2022.
  7. Studies 1/2020. Food Agency. Risk assessment of Finnish adults’ exposure to heavy metals and aluminum in foodstuffs and household water.
  8. Tuomisto J.. 2020. Health Library Duodecim. Are there still problems with heavy metals?. https://www.terveyskirjasto.fi/asy00220. Referred on 1/11/2022
  9. Koppel J. and Davies P.. 2010. Targeting the Endocannabinoid System in Alzheimer’s Disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889705/. Referred on 1/11/2022
  10. Basavarajappa BS, Shivakumar M., Joshi V. and Shivakumar S.. 2018. Endocannabinoid System in Neurodegenerative Disorders. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669051/. Referred on 1/11/2022.
  11. Aso E. and Ferrer Isidre. 2014. Cannabinoids for treatment of Alzheimer’s disease: moving towards the clinic. https://www.frontiersin.org/articles/10.3389/fphar.2014.00037/full . Referred on 1/11/2022
  12. Abate G., Uberti D. and Tambaro s.. 2021. Potential and Limits of Cannabinoids in Alzheimer’s Disease Therapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234911/. Referred on 1/11/2022
  13. Uddin Md., Mamun A., Sumsuzzman D., Ashraf G., Perveen A., Bungau S., Mousa S., El-Seedi G., Bin-Jumah MN and Abdel-Daim MM. 2021. Frontiers of pharmacology. Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer’s Disease. https://www.frontiersin.org/articles/10.3389/fphar.2020.01097/full. Referred on 1/11/2022.
  14. Nachnani R, Wesley M, Raup-Konsavage and Vrana KE. 2021. The journal of Pharmacology and experimental therapeutics. The Pharmacological case for cannabigerol. https://jpet.aspetjournals.org/content/376/2/204. Referred on 1/11/2022.
  15. Särkämö T. & Sihvonen A. 2018. Golden oldies and silver brains: Deficits, preservation, learning, and rehabilitation effects of music in aging-related neurological disorders. Cortex. Volume 109. https://doi.org/10.1016/j.cortex.2018.08.034. Referred on 21/11/2022.
  16. Nykopp J. 2015. Patient’s medical journal. Music helps to recover from brain diseases. https://www.potilaanlaakarilehti.fi/uutiset/musiikista-apua-aivosairauksista-kuntoutumiseen/. Referred on 21/11/2022
Toothache and CBD

Toothache and CBD

Toothaches have existed for thousands of years! It is definitely one of the most uncomfortable pain conditions and almost always a sign of the need for treatment. A toothache should always be taken seriously, but you can try to relieve it at home with natural means. In this article, we will learn about dental health and the possible effects of cannabinoids and CBD oil in the treatment of toothache!

What causes a toothache?

 

Usually, the cause of toothache is a hole caused by damage to the tooth enamel, which has progressed to the root of the tooth. Through the created hole, the root system and nerves can get into the pulp, which causes pain. There can be other reasons for cracking, for example a cracked tooth, a blow to the teeth or an infection at the root of the tooth. Tooth extraction also causes pain, as well as crooked or rubbing teeth can be painful and cause challenges, e.g. I bite. Nighttime teeth grinding may be accompanied by both toothache and stiffness and pain in the jaws, neck and temples. (1)

After various procedures, such as filling or tooth extraction, toothache is quite common. If it does not go away in a few days, it is necessary to contact the doctor treating the tooth again.

 

Toothache symptoms

 

The first feeling of a hole starting is a small tingling sensation caused by cold or heat, which passes in a moment. Slowly, if left untreated, the hole deepens and the swelling increases, eventually causing swelling in the jawbone. At this stage, it is usually a good idea to go to the dentist to treat the hole at the latest, because as it progresses further, the hole will drill all the way to the root, and food and drink reaching the nerve at the root will cause pain, which no painkiller can help with anymore. (1)

Inflammation of the sinus may radiate to the teeth as a throbbing pain. At its worst, the pain can cause insomnia and anxiety . A severe, unbearable toothache indicates an acute need for treatment, which is no longer worth treating only with home remedies. Then you should make an appointment with the dentist without delay and tell them about the need for immediate treatment.

Toothache can cause insomnia.

An unbearable toothache can cause insomnia and anxiety.

Backgrounds of dental health

 

Today, we are lucky to have the opportunity to correct even difficult oral problems with the help of dentistry. Effective anesthetics even offer a completely pain-free treatment experience, and regular check-ups help prevent the biggest challenges.

Things haven’t always been this good. Dental inspections only started in Finland at the end of the 19th century, and earlier information about human dental health comes mainly from archaeologists familiar with osteology and their studies. It seems that, at least during the last few centuries, human teeth have been in very bad shape already at the age of 20-30, and that is why the treatment of toothache has been one of the most important medical skills. (2)

 

Maintenance of dental health

 

Keeping your teeth in good condition is not simple, but in the end it’s all about the little things. The condition of the teeth is influenced by both genes and environmental factors, but also by your own way of caring for your teeth.

The quality of the food eaten is of great importance, and it already starts with the diet during pregnancy. Teeth need different minerals and trace elements to stay strong and shiny. When teeth are bones, they especially need calcium, magnesium, vitamins A, C and D (3).

Hunter-gatherers didn’t seem to have much of a problem with their teeth. It wasn’t until the introduction of grains to the dining table 10,000 years ago that teeth also started to change, and by no means in a positive direction. (2)

Dental care is an important part of the daily routine. In addition to brushing your teeth in the morning and evening and flossing once a day, regular oil brushing is a research-based treatment that promotes oral health.

Acid attacks, or actually the amount of them, is a significant factor behind dental health. Acid attack is caused by the reaction caused by the sugars and carbohydrates contained in the food eaten, where the bacteria in the mouth form acids that dissolve the minerals of the tooth enamel. Teeth can withstand 5-6 acid attacks a day and almost every food and drink causes them. From the point of view of the teeth, it is important to create a regular eating rhythm and stick to it, avoid constant snacking and eat treats immediately after food! (4)

 

Oil pulling with coconut oil is a popular way to clean the mouth.

Coconut oil for oil pulling. By adding CBD to the pulling oil, it can help e.g. for gingivitis, canker sores and mouth ulcers.

 

Oil pulling

 

Oil pulling is an ancient Indian Ayurvedic tradition of treating the mouth and teeth. The oil that ends up between the teeth and in the gum pockets cleans and cares for the teeth and gums, but also collects bacteria. The oil is carefully squirted in the mouth right after waking up approx. 20 minutes, after which it is spit out. (5)

For oil pulling, you should reserve an antibacterial oil, such as coconut oil. Sesame seed oil or a mixture of several oils is also often recommended. (5)

In Canada, several dentists recommend the use of CBD oil to promote dental health. Adding CBD oil to the pulling oil could be a very significant help for gingivitis, periodontitis, canker sores and ulcers, as well as promoting a good bacterial balance in the mouth. (5)

 

Drug treatment for toothache

 

A toothache can be relieved with common painkillers available at the pharmacy, but it is almost always good to find out the cause of the toothache. Sometimes the pain may be caused by food stuck between the tooth and the gum or slightly inflamed gums, but if the pain does not subside with natural means, with a standard mild painkiller or within a few days, the cause is probably something that needs to be fixed by a dentist. The medical treatment after the procedures is decided by the treating dentist!

 

Toothache home treatment

 

Toothache can also be relieved with natural means at home, but depending on the cause of the pain, it should be done carefully. Cloves are numbing, and gargling with clove water may relieve the pain, as can chewing fresh ginger. Gargling with salt water cleans the mouth and may calm swollen gums. Pressing a piece of ice inside the cloth against the cheek where the tooth hurts can also help!

According to studies, there are many ways to prevent a starting hole from growing. Gargling the mouth and teeth after eating cleans the mouth and between the teeth. Correcting the diet in a grain-free direction may help, as well as avoiding sugar and especially sugary drinks. Careful tooth brushing and interdental cleaning are the minimum requirement for healthy teeth and significantly reduce cavities, gum damage and periodontitis (inflammatory disease of the mouth caused by bacteria). (3)

By investing in home dental care, you can avoid visits to the dentist.

Regular tooth brushing and interdental cleaning significantly reduce cavities, gum damage and oral inflammatory diseases.

 

The endocannabinoid system in dental health

 

The endocannabinoid system is the body’s general regulator, which monitors the body’s functions and tries to keep everything in as good a balance as possible. The endocannabinoid system consists of endogenous endocannabinoids and their dispersing molecules, as well as cannabinoid receptors. The endocannabinoid system is also involved in the background of the functions that take place in the teeth, oral mucosa and gums.

Both cannabinoid receptors (CB1 and CB2) and endocannabinoids AEA and 2-AG are present in the mouth. A third cannabinoid receptor, GP55, has also been detected in teeth and oral mucosa. (6)

The best-known endocannabinoids are AEA or anandamide and 2AG, or arachinodylglycerol. In studies targeting the common dental disease periodontitis, it has been found that AEA has an anti-inflammatory effect on dental health, while 2AG seems to promote inflammatory processes (7).

 

CBD oil to support toothache and dental health

 

Hemp (Cannabis sativa L.) has been used especially in Asian medicine for thousands of years. It has been used for toothache and probably also for caries and to maintain general oral health. Based on current research, dental health is also affected by other active substances in hemp, such as terpenes. (6) This is called a synergistic effect and it can read more here .

CBD oil is not a miracle substance that removes toothache like a painkiller, but it may be helpful in general dental care and at the time of pain.

CBD is a cannabinoid found in hemp that has many properties that have a positive effect on health. CBD is e.g. anti-inflammatory (anti-inflammatory), antibacterial and tissue growth-promoting cannabinoid. It has also been found to have pain-relieving properties.

 

Cannabinoids

 

In addition to CBD (cannabidiol), many other phytocannabinoids have also been recognized as promoting dental health. One study compared the effects of cannabinoids and well-known toothpastes on plaque, and cannabinoids were the clear winner! The study involved CBD (cannabidiol), CBC (cannabichromene), CBN (cannabinol), CBG (cannabigerol) and CBGA (cannabigerolic acid). (8)

A study has also been conducted on mouthwashes which showed that cannabinoids are as effective or more effective than alcohol and chlorhexidine commonly used in mouthwashes (9).

CBD is also availabletoothpaste containing CBD toothpaste contains a full-spectrum hemp extract, which, in addition to CBD, also contains other hemp active substances and cannabinoids. About toothpaste and its more specific content, you can read more here.

 

summary

 

Taking care of your dental health is important, as bad teeth can even lead to a heart attack in the worst case scenario. The positive effect of CBD on dental health has been recognized, but more studies are still needed so that cannabinoids can be used even better and more widely in the future. Especially on the foreign market today, there are a wide variety of dental care products containing CBD, which may be of significant help in the prevention of various dental problems. However, the most important thing is to take care of a versatile diet and take care of your teeth daily!

 

Sources

 

  1. Könönen E.. 2021. Health Library Duodecim. Toothache. https://www.terveyskirjasto.fi/dlk00810. Referred on 19/09/2022
  2. Kimari L.. 2016. Medical magazine. Witches did invaluable work in a time before dentists. https://www.hammaslaakarilehti.fi/fi/uutinen/noitamuorit-tekivat-korvaamamonta-tyota-aikana-ennen-hammaslaakareita. referenced on 19/09/2022
  3. Honkala S.. 2019. Health Library Duodecim. Structure and development of teeth. https://www.terveyskirjasto.fi/trv00003. Referred on 19/09/2022
  4. Finnish Dental Association. Healthy eating habits. https://www.hammaslaakariliitto.fi/fi/suunterveys/yleistietoa-suunterveydesta/ravinto-ja-suunterveys/terveelliset-ruokatottumukset#.Yy9MMi06pQI. Referred on 19/09/2022
  5. VKL Shanbhag.. 2017. Oil pulling for maintaining oral hygiene – A review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198813/#__ffn_sectitle. Referred on 19/09/2022
  6. Lowe H., Toyang T., Steele B., Bryant J., Ngwa W. and Nedamat K.. 2021. The Current and Potential Application of Medicinal Cannabis Products in Dentistry. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466648/. Referred on 19/09/2022.
  7. Andrukhov O., Bantleon HP, Moritz A., Rausch-Fan X. and Özdemir B.. 2014. Endocannabinoids and Inflammatory Response in Periodontal Ligament Cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165771/. Referred on 19/09/2022
  8. Stahl V. and Vasudevan K.. 2020. Comparison of Efficacy of Cannabinoids versus Commercial Oral Care Products in Reducing Bacterial Content from Dental Plaque: A Preliminary Observation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991146/. Referred on 19/09/2022
  9. Vasudevan K. and Stahl V.. 2020. Cannabinoids infused mouthwash products are as effective as chlorhexidine on inhibition of total-culturable bacterial content in dental plaque samples. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819473/. Referred on 19/09/2022
Diabetes and CBD

Diabetes and CBD

Finland has the highest incidence of childhood diabetes in the world. In this article, we will get to know the topic of diabetes, the factors influencing its development, the endocannabinoid system behind diabetes and whether CBD oil could be helpful in managing symptoms.

 

What is diabetes?

 

Diabetes is classified as a group of metabolic diseases that involve pancreatic dysfunction and long-term elevated blood sugar. It is the seventh most common cause of death and is estimated to affect less than 10% of the entire world’s population. Type 2 diabetes in particular is rapidly becoming more common. Diabetes occurs in people of all ages, and its onset is not solely due to hereditary factors. (1,2)

Diabetes is a disease affecting the production and reception of insulin produced by the pancreas, and its different forms are numerous. The most common of them are type 1 and 2 diabetes and LADA diabetes.

 

Type 1 diabetes

 

Type 1 diabetes is a disorder of insulin production in the pancreas, where the pancreas eventually stops producing insulin completely. There is an autoimmune inflammation of the insulin-producing beta cells, which prevents the cells from functioning and eventually destroys them. Insulin replacement therapy is required for treatment. Usually, when type 1 diabetes is diagnosed, diabetes has already been present for months or years and less than one fifth of insulin-producing cells remain. (1,2)

 

Type 2 diabetes

 

Type 2 diabetes is largely a quality of life disease and its background is almost always overweight and unhealthy lifestyles. It is significantly more common than type 1 diabetes, as 75-80% of all people with diabetes have type 2 diabetes. (1,2)

In people with type 2 diabetes, the effect of insulin on its own receptors has been preserved, but numerous problems have been observed in intracellular signaling (3).

Years before the rise in blood sugar, the body has a condition called insulin resistance, which can be seen e.g. as waist obesity, fatty liver, high blood pressure and lowering of good cholesterol (1,2).

 

LADA diabetes

 

LADA-diabetes (Latent Autoimmune Diabetes in Adults) is a sort of intermediate between the two above-mentioned types of diabetes. As the name suggests, it only breaks out in adulthood, approx. 40-60 years old, and is also an autoimmune inflammation occurring in the insulin-producing cells of the pancreas. In general, LADA is interpreted as slowly developing type 1 diabetes, and its symptoms can be easily controlled with a healthy lifestyle. (1,2)

 

Gestational diabetes

 

Gestational diabetes means elevated blood sugar for the first time during pregnancy. It is determined with a sugar stress test and monitoring continues at home by measuring blood sugar. Elevated blood sugars are e.g. in the background of preeclampsia.

Gestational diabetes is caused by an increased amount of fat and hormones to which insulin production does not respond sufficiently. (4)

 

The symptoms of diabetes are listed in the picture.

The most common symptoms of diabetes are increased thirst, fatigue, exhaustion, hunger and the need to urinate.

 

Symptoms of diabetes

 

The first symptoms of diabetes are quite clear, but not unequivocal because they can also be caused by other reasons. Weight loss, increased need to urinate, constant thirst and dehydration are typical initial symptoms, which are stronger in type 1 diabetes. Based on these, blood sugar is measured, and if it is over 11/mmol, further tests are started. (1,2)

Type 1 diabetes can be fatal if left untreated. Hypoglycemia is a condition related to low blood sugar that can also lead to death. Hypoglycemia is the result of too much insulin, which lowers blood sugar to a dangerous level. Low blood sugar is caused by eating too little, alcohol, exercise and too much injected insulin, also in relation to exercise, amount of food and alcohol. (5)

 

Insulin resistance

 

Insulin resistance refers to any abnormal response to insulin in its target tissues (4). It is also called metabolic syndrome and is the basis of obesity, fatty liver and cardiovascular health in addition to type 2 diabetes. (3)

The body uses insulin e.g. to transfer sugar (glucose) from the blood to the cells. In order for the sugar to move, the body uses more insulin and it temporarily raises blood insulin levels. In insulin resistance, the cells that produce insulin can no longer meet the increased need for insulin, which is caused by the reduced ability to absorb insulin caused by the accumulated fat around the organs. (6)

 

Diabetes and the equipment and medicines intended for its treatment.

Diabetes is often treated with medication, but the importance of a suitable diet also plays an important role in keeping its symptoms under better control.

 

Diabetes treatment and medicines

 

Diabetes is treated with both drugs and diet, which is actually the basis of all treatment. Type 1 diabetes requires insulin replacement therapy, i.e. a synthetic equivalent to the insulin produced by the pancreas, but diet is an important part of successful treatment. Special attention is paid to the diet of people with type 1 diabetes and the aim is to use carbohydrates to reduce it in such a way that blood sugar remains as even as possible throughout the day and weight control is easy. (1,2) The diet of type 1 diabetics must be planned together with their medical staff!

Type 2 diabetes is also treated with medication, but it can largely be prevented and treated by following a healthy lifestyle. At the latest at the point when the first symptoms of insulin resistance start to appear, it should be necessary to make changes to at least your eating habits. The food should provide a sufficient amount of nutrients in relation to the amount of food eaten and the use of bad fats, additives and industrial sugar should be as minimal as possible.

Type 2 diabetes and also gestational diabetes can be prevented and treated by eating food that does not raise blood sugar unnecessarily. Empty carbohydrates such as pasta and rice raise blood sugar and it would be good to replace part of their amount with vegetables. You should eliminate all unnecessary sugars, hidden fats, processed products and additives from your diet and eat plenty of vegetables, fruits and berries. Appropriate quality meat and, if desired, a reasonable amount of eggs. Clean food made from raw ingredients, adequate exercise and good quality clean water.

 

Diabetes and feet

 

Foot-related side effects of diabetes account for more hospital days than all other symptoms of diabetes combined. Foot challenges are usually basically caused by pain caused by the nervous system and reduced blood circulation. Even small wounds can become badly inflamed and in the worst case even lead to limb amputation.

Foot care and prevention of problems is important for diabetics. Good shoes, careful treatment of all kinds of wounds, good hygiene and good physical condition of the feet are small but important ways to prevent bigger problems.

Foot cream containing CBD stimulates blood circulation, soothes the skin, relaxes the feet and reduces swelling.

Endocannabinoid system underlying diabetes

 

The endocannabinoid system balances the functioning of the entire body and is e.g. in the background of vital functions affecting body weight regulation, insulin resistance, fat metabolism and appetite. The situation is therefore a little complicated, because it is also a system that takes care of life in the long term and thus knows how to take full advantage of abundant times. In other words, when food is readily available, the endocannabinoid system begins to direct the mind and body in the direction that fat is stored and energy accumulates in abundance…

Referring to the above, several studies support the theory that an overactive endocannabinoid system is the underlying cause of type 2 diabetes in particular.

As a result, the body stores more energy, fat and glucose metabolism weakens, and the effects that promote cell death also increase in the beta cells of the pancreas. (7,8)

The CB1 receptor is part of the endocannabinoid system a receptor that occurs mainly in the central nervous system, but also e.g. in the spleen, lymphocytes and reproductive system. They include e.g. in the reward system, metabolic systems and fatty acid synthesis and with these also the background of diabetes. (8)

 

Symptoms related to diabetes can be eased with the help of CBD oil. The picture shows CBD oil drops.

According to research and user experience, CBD can be of considerable help in the common symptoms of diabetes, such as weight control, improving appetite and treating wounds. CBD also has a positive effect on the well-being of blood vessels.

 

CBD and diabetes treatment

 

According to animal and human studies, CBD has been found to have many therapeutic effects in the treatment of diabetes. Vasodilatation, i.e. the expansion of blood vessels, is possible when CBD activates the CB2 receptor and the serotonin receptor (5-HT1A). CBD has been found to affect diabetic neuropathy, i.e. damage to nerve function. CBD also seems to heal wounds that occur in the thin cell membrane and nerve cells of the inner wall of the intestine. In addition, CBD counteracts the nitration of tyrosine, which is involved in the accumulation of glutamate and the death of neurons. (9)

CBD is a naturally occurring cannabinoid in hemp, which has been studied to have properties that have a positive effect on health. CBD is e.g. anti-inflammatory, antioxidant and tissue-protecting cannabinoid. In addition to the aforementioned properties, CBD has been found to e.g. improving mitochondrial function and could have a significant benefit in treating and preventing complications caused by diabetes. (8)

CBD cannot directly affect insulin production, but according to studies and user experiences, it can be useful for general symptoms such as weight control, appetite and wound treatment. CBD also has a positive effect on vascular health.

Cosmetics containing CBD can help with foot challenges such as nerve pain, skin condition and peripheral blood circulation improvement. A foot cream that contains CBD can be a product worth trying also as a preventive treatment.

 

Summary

 

Type 2 diabetes is becoming more and more common among younger people, and since it is largely a disease caused by lifestyle, prevention and treatment is quite possible and not at all difficult. Changing lifestyles requires persistence, but it’s not rocket science. CBD can be a good help, especially for the side symptoms of diabetes such as challenges related to the feet, but more research is still needed on how CBD affects diabetes overall and the factors behind it.

 

Sources

  1. Pirjo Ilanne-Parikka. 2021. Duodecim Health Library. https://www.terveyskirjasto.fi/dlk00011. Referred on 30/08/2022
  2. Diabetes. Diabetes Association. https://www.diabetes.fi/diabetes. Referred on 30/08/2022
  3. Mäkinen S., Skrobuk P., Nguyen T. and Koistinen H.. 2013. Duodecim periodical book. Mechanisms of insulin resistance. https://www.duodecimlehti.fi/duo11275. Referred on 30/08/2022
  4. Diabetes Association. Diabetes.fi. Gestational diabetes. https://www.diabetes.fi/diabetes/raskausdiabetes. Referred on 30/08/2022
  5. Mustajoki P.. 2022. Doctor’s book Duodecim. https://www.terveyskirjasto.fi/dlk00886. Referred on 30/08/2022
  6. Diabetes Association. Diabetes.fi. Metabolic syndrome. https://www.diabetes.fi/diabetes/tyypin_2_diabetes/metabolinen_oireyhtyma_mbo. Referred on 30/08/2022.
  7. Frisher M., White S., Varbiro G., Voisey C., Perumal D., Crome I., Khideja N. and Basford J.. 2010. The British journal of diabetes and vascular disease. The role of cannabis and cannabinoids in diabetes. https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13226. Referred on 30/08/2022.
  8. Gruden G., Barutta F., Kunos G., and Pacher P.. 2016. Role of the endocannabinoid system in diabetes and diabetic complications . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941127/. Referred on 30/08/2022.
  9. Atalay S., Jarocka-Karpowicz and Skrzydlewska E.. 2019. Antioxidative and Anti-Inflammatory Properties of Cannabidiol. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/#B25-antioxidants-09-00021 . Referred on 8/10/2022
Autism and CBD

Autism and CBD

Autism and the autism spectrum are associated with a number of different neurological disorders, which usually complicate the life of the sufferer. The spectrum of autism includes various factors affecting the ability to function, which can vary individually with large differences. Even perfectly healthy people are very different in many ways, and the same applies to autistic people. Everyone has their own individual traits and ways of experiencing the world.

Some of those diagnosed with autism spectrum disorder are able to live independently, while some need help to survive in everyday life throughout their lives. An autistic person’s need for help can vary, e.g. depending on life situation, age and support measures. (1)

The word spectrum refers to the variation and intensity of symptoms arising from disorders. Autism spectrum disorder is recognized much more often in men than in women. Out of the entire population in Finland, less than one percent (0.7%) of the population suffers from autism. It is not yet known exactly what causes the differences in prevalence, but it is thought to be related to biological differences between the sexes. (2)

 

Traits of autism

 

Autism affects a person’s way of experiencing and sensing the environment. Most of the time, the interaction and communication of an autistic person differs from “normal”, so to speak.

Common features for autistics are e.g. difficulties in controlling one’s own activities, difficulties in social situations (communication), a different way of interpreting and sensing situations, and sensitivity to nervous system overload and stress. However, the features vary from case to case. (1)

Autism features also include areas that can manifest as exceptional talent, such as the ability to pay attention to details and solve even difficult puzzles. In addition to them, autistic people can have excellent concentration and a clear understanding of right and wrong. (1)

 

The characteristics of the spectrum of mild autism in a child can be determined with the help of research.

Common features for autistic people are difficulties in controlling their own activities, communication difficulties, and sensitivity to nervous system overload and stress.

 

Autism spectrum disorders

 

Autism spectrum disorders (Autism Spectrum Disorders, i.e. ASD) and related brain development disorders become apparent at an early stage. The characteristics and challenges in functioning of autistic people can vary significantly.

List of autism spectrum disorders:

  • Autism
  • Asperger syndrome
  • Pervasive developmental disorder (atypical autism)
  • Pervasive Developmental Disorder Not Specified (PDD-NOS)
  • Rett syndrome
  • Disintegrative developmental disorder (Heller’s disease)

 

There is not only one clear cause behind the disorders, but several biological factors influence it. Although the exact causes have not yet been identified, in any case, hereditary factors influence the prevalence of the disorder. According to current data, 65-90 percent of autism spectrum disorders are inherited. (2)

In the entire population, the autism spectrum is observed in about 1 percent of people. In developed countries, the number is higher (1.5%) and has almost doubled in 10 years. (3)

 

Asperger syndrome

 

Autism-related diagnoses have become more specific. Once thought of as a rare childhood disorder, Asperger’s syndrome is now classified as a lifelong illness. The syndrome in question was named after the Austrian pediatrician Hans Asperger and was introduced in Finland in the 1990s.

Asperger’s syndrome and autism are now classified as part of the autism spectrum disorder and those terms have been removed from the classification (ICD-11 and DSM-5). The autism spectrum is defined on a case-by-case basis from mild to severe. (3)

 

Symptoms of Autism

 

Autism-related symptoms usually appear already during early childhood, within the first three years of age. Sometimes the symptoms are only noticed in preschool or later. An autistic child usually has difficulty understanding verbal and non-verbal communication. Often, maintaining eye contact has also proven to be challenging. (2)

The symptoms related to autism are therefore especially manifested in social situations and interactions with others. The disorder may include certain repetitive behaviors and special interests that an autistic person easily becomes immersed in. Each person suffering from autism spectrum disorders has their own characteristics, and some may live very independently, while others may have a great need for help with everyday tasks. (2)

 

The most common symptoms related to autism spectrum disorder

 

  • Difficulty understanding the feelings and thinking of others
  • The challenges of starting and maintaining a conversation
  • The difficulty of working in a group
  • Difficulty accepting new situations and changes
  • Avoiding eye contact
  • Little use of sign language and facial expressions
  • Difficulty forming lasting friendships. (4)

 

It is also possible that the symptoms are not noticed until later in life, when the pressures of working life or postgraduate studies increase. Potential disorders should also be diagnosed by adults, so that work, study and the necessary measures related to rehabilitation can be planned in the necessary way and the risk of being marginalized can be prevented. (3)

 

Autism is diagnosed and tested using various tests for both children and adults.

Getting a diagnosis of autism spectrum disorder is a multi-step process that is done together with the help of an expert doctor. Various tests, examinations and interviews are needed for diagnosis.

 

Autism test

 

Although the symptoms of autism spectrum disorder usually become apparent at an early stage, no specific age limit has been set for its definition. It is possible to make the diagnosis even for an adult, and for that there are tests that support the definition of autism. (5)

If you suspect an autism spectrum disorder in yourself or someone close to you, the general recommendation is to seek a doctor’s consultation and prepare for the appointment by thinking about and writing down all the observed features classified as autism spectrum that occur in everyday life. The doctor has the option of separately requesting an appointment with a neuropsychologist, where the matter can be examined in more detail with the help of various examinations. (5)

Getting an official diagnosis is a multi-step process and is usually done with the help of a doctor familiar with the subject through various examinations and interviews. In addition, the diagnosis often also requires interviewing close people, seeing a psychologist and therapist. In the studies, special attention is paid to functional ability, communication, interaction skills and interests throughout life. School certificates, birth records and other documents related to growth and development should be included to make the process easier, as comprehensive examinations to make a diagnosis often require a lot of time. (5)

 

Screening

 

There are various tests and screening tools to support the diagnosis of autism spectrum disorder. Filling out the form can make the doctor’s work easier and speed up the diagnosis.

In the links below, you can find screening forms to support the definition of autism in children and adults.


Digital CHAT evaluation form (in Finnish)

 

Digital M-CHAT-R extended evaluation form , (in Finnish)

 

The AQ-10 screening form intended for adults may be helpful at the doctor’s office when assessing the need for additional tests to make a possible diagnosis in an adult who does not have major learning difficulties.

AQ-10 evaluation form for identifying the autism spectrum in adults

 

The ASSQ screening form, designed for parents of children, can clarify and be helpful in the diagnosis of autism spectrum disorders.

ASSQ assessment form for parents

 

The GQ-ASC screening form below is designed to identify autism-related behaviors and abilities in cis and trans women.

GQ-ASC assessment form (cis and trans women)

 

An autistic child is playing on the floor. A person with an autism spectrum disorder can get help from CBD oil.

An autistic child easily drifts into playing only his own games. In the behavior of an autistic child, deficiencies are also often observed in relation to language development and making eye contact.

 

An autistic child

 

Some autistic children manage well independently, while others may need daily support. At worst, an autistic child can also significantly challenge the lives of the child’s loved ones. (1)

In addition to genetics, there are also physiological factors involved in the manifestation of autism. Upbringing has not been found to have a connection with the prevalence of autism. (1)

Autism may appear in a child very early, before the age of 1 year. In general, deficiencies are noticed in the behavior of autistic children, e.g. in eye contact, language development and the way they play with other children. The child may also have a different way of answering questions and expressing emotions. An autistic child may get irritated easily and drift off to play only his own games. The importance of familiar and repeated routines is emphasized in an autistic child. (6)

 

Autism treatment

 

Autism spectrum disorders are congenital, and no curative treatment has yet been invented.

In the revised disease classification, autism is not currently separated into separate diagnoses and e.g. Asperger’s syndrome, a mild form of autism, is now considered part of the autism spectrum disorder.

Although there is no known cure for autism spectrum disorders, its symptoms can be alleviated and individual development can be supported with, for example, occupational therapy and speech therapy. In addition, it is important for an autistic child and his parents to accept the prevailing situation and learn to live with the personality traits that are associated with it. (7)

If the symptoms significantly challenge everyday life, it is worth discussing the matter together with an expert neuropsychologist, with whom the treatment of the situation and the need for different forms of support can be planned in an appropriate way. Usually, support and rehabilitation takes place in cooperation with kindergarten, healthcare or school. (7)

The control of one’s own actions and the development of the brain continue until at least the age of 25. The symptoms related to the autism spectrum may decrease after reaching adulthood, if the child receives the necessary support along the way and participates in a rehabilitation program. In some cases, with the help of successful rehabilitation and support, the symptoms can decrease so much that the previous diagnosis no longer matches the picture of the symptoms. (7)

 

Autism spectrum treatment with CBD

 

Symptoms of the autism spectrum are currently also treated with CBD products such as CBD oil and CBD capsules. This alternative and natural form of treatment has spread worldwide in popularity, when several doctors and parents of autistic children have publicly shared their positive experiences and results related to autism treatment.

Some studies have shown that cannabinoid products reduced the number and/or intensity of symptoms associated with the autism spectrum, including hyperactivity, self-harm, sleep disturbances , feelings of anger, anxiety , irritability, restlessness , psychomotor agitation, aggression, and depression .. In addition, they observed improvement in cognition, sensory sensitivity, attention, social interaction and language. The most common side effects were sleep disturbances, restlessness, nervousness and changes in appetite. (8)

Especially for minors, the safety of using CBD should always be evaluated on a case-by-case basis together with an expert doctor.

CBD is hardly a panacea that cures the disorder completely, but for many it seems to be a significant help in everyday functioning and in alleviating the symptoms. Read more in the next paragraph about how the endocannabinoid system and autism are connected.

 

The role of the endocannabinoid system in autism

 

The vital functions of almost every animal are controlled and balanced by an internal cannabinoid system. It is absent only in insects and protozoa. Complicated endocannabinoid system consists of a network of receptors covering the entire body, which are affected by neurotransmitters. It is known to influence and regulate e.g. brain, kidney, liver and immune system function. (9)

Based on new evidence, people with autism spectrum disorder have anandamide the amount found to be lower than in a healthy control group. Anandamide is an endocannabinoid, also known as the happiness molecule, or internal cannabinoid, and based on this research result, the internal cannabinoid system and the imbalance of cannabinoids can have an effect on the manifestation of the disorder. (10)

Autism-related disorder has also been linked to the amount of oxytocin in the body. Oxytocin, also known as the love hormone, is a neuropeptide consisting of amino acids that is expressed in mammals and acts as a messenger and hormone. Oxytocin is produced in the brain’s hypothalamus, from where it passes through the pituitary gland into the bloodstream. Today it is known that oxytocin plays a significant role in e.g. in the formation and maintenance of the attachment relationship between the child and its parents. In addition to that, oxytocin is also associated with social, emotional, cognitive functions. Since the production of oxytin is also regulated by the internal cannabinoid system, you can from CBD and some others of cannabinoids be useful in connection with its normal production. (11)

Researchers think that the interaction between anandamide and oxytocin and the correction of their deficiency states related to autism could provide relief in treating the symptoms (11).

The internal cannabinoid system also seems to play an important role in relation to social interaction skills and emotions, which CBD and certain cannabinoids can activate. By affecting the receptors of this body system, it may also have an effect on alleviating the symptoms of autism.

 

THC and autism

 

Although research is still ongoing, there are indications that THC-cannabinoid may reduce internal anandamide concentrations in the body. The concentrations of anandamide are already low in people with autism, so it should be avoided the continuous use of THC. Anxiety is also a common symptom associated with autism, and THC and THCV may make it worse for some. However, the experiments were done on rats and with strong THC-containing cannabis products, so how it affects humans is not yet fully understood.

Generally, in CBD oils, the traces of THC are minimal enough to be detrimental to anandamide levels. Understanding the issue is also complicated by the fact that, according to studies, full-spectrum CBD products are prone to side effects (see entourage effect) are therefore more effective for many diseases and imbalances in the body than isolated cannabinoids (isolates). Full spectrum means that the final product also contains THC, although often only in very small amounts.

If you are considering CBD products for the treatment of an autism spectrum disorder and want products containing as little THC as possible, you should consider CBD products activated by heating, because their THC concentrations are usually significantly lower. See more about how heating works decarboxylation affects the final product.

Sources

 

  1. Autism Association. 2022. Basic information about autism. https://autismiliitto.fi/autismi/perustietoa-autismista/. Referred on 12/09/2022
  2. Health house. Autism and autism spectrum disorders. https://www.terveystalo.com/fi/tietopaketit/autimi-ja-autismikirjon-hairiot/#Mit %c3% a4 %20on% 20autismin%20kirjo . Referred on 12/09/2022
  3. Hanna Raaska & Raija Vanhala. 2020. Medical journal. Why and how do the diagnostic criteria for autism change? https://www.laakarilehti.fi/tieteessa/katsausartikkeli/miksi-ja-miten-autismin-diagnostiset-kritierit-muuutuvatt/?public=7fcf41d96a001eee7da91094299e5b86 . Referred on 08/12/2022
  4. Mielenterveystalo.fi. Autism spectrum disorders (ASD). https://www.mielenterveystalo.fi/lapset/ammattilaisille/hairiot/autismikirjon_hairiot/Pages/autisimikirjon_hairiot_ASD.aspx. Referred on 13/09/2022
  5. Autism Association. 2022. Diagnosing the autism spectrum. https://autismiliitto.fi/autismi/diagnosointi/. Referred on 13/09/2022
  6. Autism Association. 2022. Autism in different stages of life. https://autismiliitto.fi/autismi/autismikirjo-eri-elamanvaiheissa/. Referred on 09/04/2022.
  7. Pekka Räisänen & Ulla Boshkov. Autism in a child. https://www.mehilainen.fi/lasten-mehilainen/autismi-ja-autismikirjo. Referred on 13/09/2022
  8. Estácio Amaro da Silva Jr. and others 2022. Trends Psychiatry Psychother. Cannabis and cannabinoid use in Autism Spectrum disorder: a systematic review. https://pubmed.ncbi.nlm.nih.gov/34043900/. Referred on 15/09/2022
  9. Ethan Russo. 2015. Phytecs. Introduction to the Endocannabinoid System . https://www.phytecs.com/wp-content/uploads/2015/02/Russo-Introduction-to-the-Endocannabinoid-System-corr-January-2015.pdf . Referred on 14.09.2022
  10. Debra S. Karhson et al. 2018. Molecular Autism. Plasma anandamide concentrations are lower in children with autism spectrum disorder.https://molecularautism.biomedcentral.com/articles/10.1186/s13229-018-0203-y. Referred on 15/09/2022
  11. Don Wei et al. 2015. Pnas. Endocannabinoid signaling mediates oxytocin-driven social reward. https://www.pnas.org/doi/full/10.1073/pnas.1509795112 . Referred on 15/09/2022
Anti-inflammatory CBD

Anti-inflammatory CBD

One of the most well-known and researched properties of CBD is the reduction of inflammation. The body’s inflammatory reaction is very common and occurs with every small wound, but sometimes it contributes to the emergence of diseases! In this article, we will learn about different types of inflammation, the endocannabinoid system behind inflammation, and how CBD can reduce inflammation in the body.

 

What is inflammation?

 

Inflammation is the body’s natural reaction against an external pathogen, which originates from messages from the tissue level about dangerous situations. Activated immune cells produce both anti-inflammatory and pro-inflammatory mediators and this is regulated endocannabinoid system (1). The purpose is that the inflammatory reaction would only be a quick transient situation where the pathogen is eliminated, because if it continues for a longer time it causes damage to the tissues. (2)

There are huge numbers of cells in the human body that control the functioning of the body through messages through the nervous system, and inflammation alone is caused by dozens of different messengers and enzymes. CBD has been found to affect several different inflammatory pathways, while often drugs, for example aspirin, only affect one pathway (1).

 

What causes inflammation?

 

There are different types of inflammation and they can be caused by many different reasons. Next, we will go through slightly different types of inflammation.

Wound inflammation

 

The mechanism behind all inflammations is the same. A microbe enters the body, which causes a natural reaction. However, an inflamed wound is not the same as the inflammatory reaction associated with normal wound healing, which is essential for healing. If dirt remains or gets into the wound, or if it does not heal properly for one reason or another, the body starts to form an inflammation as a reaction, which may spread widely if left untreated. (3)

 

Local inflammations

 

Viruses and bacteria sometimes cause local inflammation, which is usually acute and sometimes resolves on its own. For example, in bronchitis, a bacterium causes inflammation of the mucous membranes of the bronchi and larynx, onychomycosis is caused by bacteria that got under the nail, and tendonitis is caused by stress.

Chronic inflammation in the elbow that CBD can relieve.

According to research, CBD can effectively reduce chronic or low-grade inflammation.

 

Low-grade or chronic inflammation

Low-grade inflammation in the body is also called chronic or silent inflammation and is mainly caused by bad lifestyles and lack of exercise. It is not an actual disease in itself, but a state of the body in which inflammatory mediators are secreted more than necessary. (4)

The background of chronic diseases is often elevated inflammatory markers and inflammatory mediators, and inflammation is the background of many long-term illnesses. These diseases and The effect of CBD on them has been extensively studied with positive results.

CBD and also other cannabinoids available from hemp have been found to have therapeutic effects on many inflammatory diseases (5). Such are e.g. psoriasis, MS and rheumatoid arthritis . Inflammatory intestinal diseases such as Crohn’s disease may also be relieved with the help of CBD. Today, it is known that inflammation also plays a role in the background of depression .

 

Symptoms of inflammation

 

Symptoms of wound inflammation include pain at the wound site, spreading redness and often suppuration of the wound. The inflammation may also raise the fever. An untreated inflamed wound can cause blood poisoning and, in the worst case, even amputation of a limb. (3)

Low-grade inflammation in the body causes both diseases and milder symptoms. This condition is often called silent inflammation because it does not cause the same visible and palpable symptoms as, say, an inflammation of a wound. Silent inflammation develops slowly and can exist for years before symptoms actually appear. Often mysterious skin problems, overweight, allergic symptoms without allergies, elevated cholesterol and blood pressure values give indications that there may be low-grade inflammation in the body. (4,6)

Local inflammations are associated with symptoms of inflammation that are very different depending on where the inflammation is located. Appendicitis is felt in the stomach, urethritis when urinating and tooth infection in the jaws. Many infections heal on their own, but if the symptoms continue for a long time, become intense or cause unbearable pain, you should find out with your doctor whether acute treatment is needed.

 

Symptoms of arthritis in the hands.

Slow-developing silent inflammation develops slowly and can exist for years before its symptoms begin to appear. Several skin problems, overweight, allergic symptoms, elevated cholesterol and blood pressure values point to low-grade inflammation.

 

The most common infections

 

Inflammation is a very common reaction and is also associated with many acute underlying diseases and viral infections. The most common ones are e.g. ear infection, kidney basin, gall bladder, inflammation, eyelid, tear duct and cornea infections, appendicitis, small intestine and colon infections. Common infections such as root canal and gingivitis also occur in the mouth.

 

Treatment of inflammation

 

Inflammations are treated in different ways, depending on what kind and where it is. Often the infections will heal on their own, but sometimes natural treatments or medicines are needed.

It is important to clean the wounds properly and protect them from dirt until they heal. A wound also needs oxygen to heal, so it is not good to cover the wound at least constantly, but to give it air when changing the bandages. In the treatment of a wound, pitch ointment has been found to be very good, as well as various herbal patches such as the leaf of the gardenia plant can speed up the healing of the wound. (3,7).

Depending on the inflammation, local inflammation can be treated with either home remedies or antibiotics. It is always good to treat a serious infection with a doctor, but mild and incipient infections may be treated, for example, with the help of various herbs and plants such as rosemary, elderberry and sage. Various infections are also treated successfully with homeopathy.

 

Medicines that reduce inflammation

 

Medicines that reduce inflammation can be found in both antibiotics and over-the-counter medicines at the pharmacy. Many common painkillers are also anti-inflammatory and reduce fever, while they affect the sensation of pain. Such drugs include e.g. Burana, Ibuxin and Aspirin. Medicines available without a prescription should not be used to treat the inflammation for more than a few days, especially if the symptoms continue to be severe. If necessary, the inflammation should be medicated and treated with the help of a doctor.

 

Diet and lifestyle changes

 

When the body is in good shape and the body feels good, even wounds heal faster and cleaner. Although correcting lifestyles contributes to the healing of chronic inflammation while also preventing it, the change in life has a positive effect on the entire immunity and thus also on susceptibility to illness.

Inflammation can also be alleviated with the help of diet. Foods that reduce inflammation include e.g. various berries (blueberries, strawberries, raspberries), fatty fish (salmon, herring), ginger, turmeric, dark chocolate, broccoli, avocado, green tea, chilies, peppers, grapes, olive oil, and many herbs.

 

Endocannabinoid system underlying inflammation

 

The endocannabinoid system is a body balancer system found in all mammals that monitors all body functions. In the event of an accident, the endocannabinoid system is the one that sends the necessary cells to the wound and points out that the wound has now been healed enough. It doesn’t actually do anything by itself, but is in the background monitoring and regulating various body functions so that the healing is as optimal, effective and fast as possible.

The endocannabinoid system is involved both in the creation of inflammation, but also in its prevention. Its functions as an anti-inflammatory are related to preventing cytokine production, preventing cell proliferation and regulating cell death. The endocannabinoid system regulates the inflammatory response by preventing excessive activation, proliferation and migration of immune cells in the body, and by activating the death of immune cells. Endocannabinoids regulate the inflammatory response at both the innate and adaptive immune levels. (1)

Endogenous cannabinoids, or endocannabinoids, prevent the production of pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines throughout the inflammatory response. (8,9)

 

Anti-inflammatory CBD

 

Chinese doctors have already said thousands of years ago that hemp eliminates rheumatism. One way or another, different cannabinoids have been found to have anti-inflammatory or anti-inflammatory effects. Also with other cannabinoids such as for example CBG (cannabigerol) has been found to have both anti-inflammatory and antioxidant properties.

CBDhas been studied extensively specifically in relation to inflammatory diseases. It does not actually affect our body through the endocannabinoid system’s own receptors CB1 and CB2, but through other receptors such as serotonin receptors. Inflammation involves the cooperation of CBD and the GRP55 receptor, as well as the interaction between the TRPV receptor and CBD. (1,8,9)

The antioxidant effects are related to CBD’s free radical blocking and transforming effects. CBD breaks their chain reactions, captures them and converts them into less active forms. (8)

CBD also supports the activity of antioxidant enzymes by preventing the reduction of trace element concentrations. CBD has been found to be an even stronger antioxidant than vitamins A and C. (8)

 

CBD oil bottles to treat inflammation.

CBD has been found e.g. reducing the levels of pro-inflammatory cytokines, preventing the proliferation of inflammation-related cells and promoting their death.

 

Does CBD oil help with inflammation?

 

In the case of inflammations, dosage probably plays a big role in terms of success, and inflammations are often treated with quite large doses.

The action of CBD oil in the body supports the activity of the endocannabinoid system and has been found to increase the endocannabinoid anandamide levels, which in turn affects cannabinoid signaling. This is also why CBD oil promotes anti-inflammatory and anti-inflammatory effects. (1,8)

Studies have shown that CBD oil reduces the levels of cytokines that promote inflammation, prevents the proliferation of cells associated with inflammation, promotes their death, and reduces the movement and activity of immune cells. (9)

 

in summary

 

Inflammation is a necessary and completely natural reaction, but sometimes inflammation can even cause long-term illnesses. It is possible to treat inflammations with gentle home remedies, but they are also treated with, for example, antibiotics and homeopathy.

CBD oil and CBD have been extensively studied for their anti-inflammatory properties and have been shown to have therapeutic effects. CBD oil is generally a well-tolerated and gentle form of treatment, which may be of significant help for severe inflammatory diseases such as MS and arthritis.

 

Sources

 

  1. Chouinard F., Flamand N., Lefebvre JS and Turcotte C.. 2015. Journal of Leukocyte Biology . Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol, arachidonoyl-ethanolamide and their metabolites. https://jlb.onlinelibrary.wiley.com/doi/pdf/10.1189/jlb.3RU0115-021R. Referred on 8/10/2022.
  2. Hänninen A.. 2011. Period book Duodecim. Immunological regulation of the acute inflammatory response. https://www.duodecimlehti.fi/duo99721. Referred on 8/10/2022.
  3. Acute wound inflammation. Health village. https://www.terveyskyla.fi/haavatalo/tietoa-haavoista/akuutit-haavat/akuutin-haavan-paranemista-hidastavat-syyt/akuutin-haavan-tulehdus. Referenced 1/10/2022
  4. Uusitupa M. and Schwab U.. 2014. Period book Duodecim. Diet and mild inflammation. https://www.duodecimlehti.fi/duo11787. Referred on 8/10/2022.
  5. Henshaw FR, Dewsbury LS, K.Lim C, and Steiner GZ. The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of In Vivo Studies. 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266561/. Referred on 8/10/2022.
  6. Low-grade inflammation can underlie many diseases. Zip. https://www.puhti.fi/tietopaketit/matala-asteinen-tulehdus/. Referred on 8/10/2022.
  7. Lohi J., Jokinen JJ, Sipponen A., Mäki-Paakkanen J., Peltola R., Rautio M., Laakso T., Saranpää P., Papp A. and Sipponen P.. 2008. Period book Duodecim. Effects of spruce resin ointment on wound healing. https://www.duodecimlehti.fi/duo97315. Referred on 8/10/2022.
  8. Atalay S., Jarocka-Karpowicz and Skrzydlewska E.. 2019. Antioxidative and Anti-Inflammatory Properties of Cannabidiol. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/#B25-antioxidants-09-00021. Referred on 8/10/2022
  9. Lorena C ., Robaina C., Keir-Rudmana S., Hornimanb N. and Clarkson C.. 2021. The anti-inflammatory effects of cannabidiol and cannabigerol alone, and in combination. https://www.sciencedirect.com/science/article/abs/pii/S1094553921000596. Referenced 1/10/2022
CBD oil to support cancer treatments

CBD oil to support cancer treatments

According to the World Health Organization, cancer is the second most common cause of death in the world, and currently around every third person will get it during their lifetime. CBD and the endocannabinoid system have been widely studied in relation to cancer. This article examines the endocannabinoid system in the context of cancer, what cancer is and whether CBD oil could help manage cancer or cancer-related symptoms.

What is cancer?

Cancer is an umbrella term for a large number of different diseases. People with uniform cancer only have an uncontrolled distribution of cells in the body, otherwise the cancer can be anywhere, any kind and with a wide spectrum of different symptoms.

Cancer is especially a disease of the elderly, but it occurs in people of all ages, from babies to adults. Today, the prognosis for survival and recovery is good, and more and more people are making a full recovery as treatments develop. Nevertheless, it is thought that in the next few years, cancer will overtake even heart diseases in the death statistics. (1)

A benign tumor remains in place, grows moderately and is usually easy to treat. A malignant tumor forms metastases and the dividing cells spread to other parts of the body, becoming part of the body, while a benign tumor remains as its own separate body, isolated from itself by the body’s healthy cells and tissues.

 

The most common types of cancer

 

There are many different types of cancer and they are named according to where they originate. Prostate cancer is the most common in men, breast cancer in women. Cervical tumors also occur in women. Lung cancer is one of the most common, and colon and rectal cancer are the most common intestinal cancers. Less common, but common are e.g. bladder, kidney and esophageal cancer. (2)

 

Where does cancer start?

 

Tumor growth starts from a single cell, which begins to divide uncontrollably. It is usually a slow chain of events in which the information the cell inherits about cell growth and division is damaged. (1)

Genes located on chromosomes are behind everything. Human hereditary factors, i.e. genes, control the functioning of the cell and sometimes mutations occur in genes. When there are enough of these mutations in the same area of the body, they start to form a tumor. (1)

Gene activity is influenced by environmental factors such as the air we breathe, the food we eat and the atmosphere we live in. (1)

The acidity of the body is one factor in the development of cancer. The body is strongly alkaline when a child is born and it slowly becomes acidic towards old age. Acidification is natural, but it happens faster due to the influence of the environment, such as as a result of drinking a lot of coffee and unhealthy food.

 

Cancer and its many symptoms

 

The symptoms of cancer can actually be anything depending on its location. In all types of cancer, the symptoms are also different among patients, but usually they appear in the area of the body where the tumor is located. In skin cancer there are changes on the skin, in brain tumors there are disturbances in the body’s functions, in lung cancer there may be cough and breathing difficulties, in intestinal cancer bloody stools or digestive problems, etc. (1,2)

Common symptoms of cancer include e.g. pains, general weakness and loss of appetite. In addition to cannabinoids have been studied in terms of tumor eradication, their use has also been extensively studied to treat general symptoms.

 

Symptoms of the final stage of the disease

 

When it has been determined that the cancer cannot be treated medically, palliative treatment is usually used, i.e. treatment that relieves symptoms and improves quality of life. It includes alleviation of pain and symptoms, and e.g. fulfilling psychological, social and spiritual needs.

However, there is always hope. The most touching healing stories can be found on social media and blogs on the internet. People who received a death sentence from a cancer diagnosis share their own experiences of how they have miraculously recovered from cancer. Others say they drank conifer extract drink, others carrot-apple juice. Some have healed themselves with diet and supplements, and some even with fasting. What all these happy ending stories have in common is that these people sincerely trusted in their own healing. They have had hope, faith and gratitude for life and the power of healing.

According to user experiences, CBD oil is a good supportive treatment alongside palliative care, as it has been found to help precisely those symptoms that occur most often.

 

In the picture, a cancerous tumor in the lungs modeled on a computer.

Cancer can be diagnosed with a combination of different research methods, such as blood tests, imaging and test pieces. The image shows lung cancer modeled on a computer.

 

Does cancer show up in blood tests?

 

Cancer research has developed enormously in recent decades. The tumor is verified with a combination of research methods, including blood tests, scanning and taking samples.

Blood tests are already taken at the stage when cancer is suspected and cancer type markers are looked for, possible elevated kidney and red blood cell values are examined, and the concentration of blood storage iron, or ferritin, is measured. (1)

 

The endocannabinoid system and cancer

 

The endocannabinoid system is the body’s security system, whose task is to monitor and balance all the functions that take place in our body. It is present in almost all animals and humans in the world, and its malfunctions are thought to be somehow involved in all diseases of both body and mind.

In several studies, the involvement of the endocannabinoid system in the origin and development of cancer has been demonstrated. Endocannabinoids and their receptors have been noticed to increase during cancer, which of course does not mean that the endocannabinoid system is actually involved in the worsening of cancer. Rather, the more endocannabinoids and receptors there are in a tumor, the more aggressive the tumor is. Endocannabinoids and the receptors that receive them are, as it were, in a larger group resisting this disease that consumes the body. (3,4)

The endocannabinoid system and its communication has been found to be involved in the regulation of cell survival, movement and death. (3,4,5)

 

Cannabinoid receptors

 

Cannabinoid receptors are everywhere in the body. CB1 receptors are mainly found in the brain, while CB2 receptors are common in tissues responsible for the immune system. Both receptors are present in tumors, but the regulation of cancer progression seems to be mainly controlled by the CB2 receptor. (4)

On a general level, we could say that both CB receptors (CB1 and CB2) and their endogenous ligands increase in tumor tissues. Their overexpression is directly related to the aggressiveness of the tumor, and the levels of the receptors can be used to predict e.g. probability of survival. (4,7)

 

Other body receptors

 

Almost all functions in the body go through receptors. There are many different types and they all have their own important tasks. A few receptors that are essentially related to cancer have been raised here.

 

TRPV receptors

 

TRPV channels are common receptors in the body. This family includes six different channels and they are numbered TRPV1, TRPV2, etc.

TRPV receptors are strongly associated with CBDand in its antitumor activities. In different types of cancer, cell death occurs through different pathways, but usually it is dependent on the activity of one of the TRPV channels. Depending on the location and quality of the tumor, some kind of combination of receptors is usually used. It has been noticed that sometimes CBD uses, for example, CB1, CB2 and TRPV1 receptors, while in the case of another tumor it uses CB2 and TRPV2 receptors. This is a great demonstration of the complexity of how the endocannabinoid system works! (3,6)

 

GRP55

 

GPR55, also called the third CB receptor, and its amount in the body is related to the rapid proliferation and movement of tumor cells in several types of tumors (4,6). In general, the effect of CBD depends on the combination of these receptors.

 

Endocannabinoids

 

Endocannabinoid levels vary greatly between different tumor types.

The levels of the most well-known endogenous cannabinoids AEA (anandamide) and 2-AG (2-arachidonylglycerol) have been found to be either lower or higher in tumors compared to healthy tissue (4,7). Endocannabinoids also work in pairs or groups and thus create an interactive effect. For example, the combination of anandamide and oleamide inhibits cell proliferation. (7)

 

Endocannabinoid system in cancer treatment

 

It has been stated several times in studies that treatments targeting the endogenous cannabinoid system are the future. According to many studies, the background of all body imbalances manifested as diseases is some degree of disturbance in the endocannabinoid system, which is why specific treatments aimed at it could be very effective. However, more research is needed, because there are always questions, especially with synthetic single endocannabinoids and exocannabinoids. Hemp has been found to work best synergistically i.e. so that all the beneficial substances in the plant such as cannabinoids, terpenes, flavonoids, etc. are used by the body.

Synthetic, i.e. man-made preparations that mimic endocannabinoids have brought good results in drug tests, despite the fact that their mechanism of action is a complex mystery. They have been reported to reduce tumor growth and aggressive metastasis. Synthetic inhibition of MAGL and FAAH enzymes, the natural degraders of endocannabinoids, has also shown anticancer activity. (3,4,6,7)

 

CBD oil to support cancer treatment. Image of bottle of CBD oil.

CBD, one of the most studied cannabinoids, has been found to have strong effects on cancer cells, as well as the ability to prevent the formation of metastases.

 

Cannabinoids in cancer treatment

 

Several studies suggest that cannabinoids are able to suppress inflammatory responses by reducing the production of cytokines and chemokines and increasing T-regulatory cells. Similar results were also obtained with endocannabinoids.

The effect of cannabinoids on inhibiting tumor growth has been demonstrated in both benign and malignant tumors. Cannabinoids can induce natural cell death and prevent the tumor’s own blood vessels from forming. (7)

Cannabinoids have been found to be effective e.g. you can read more about the treatment of insomnia here. They may also help with various pains, which you can read more about in the article Pain and CBD oil.

CBD

 

CBD (cannabidiol) is one of the most studied external cannabinoids in the body. CBD has been found to have strong proapoptotic effects. Apoptosis is the natural death reaction of cells, as a result of which cancer cells also die. CBD is also antiproliferative, meaning it prevents cells from multiplying. (3,6,8)

As an antiangiogenic CBD prevents the formation of new blood vessels in the tumor area, and as it is also anti-metastatic, it prevents the formation of metastases. (3,6,8)

The use of CBD shows, in the light of research, that it increases the possibility of survival, and mitigates several side effects of different cancer and cancer treatments.

CBN, CBC and CBG

 

The lesser-known cannabinoidsCBN (cannabinol), CBC (cannabichromene) and CBG (cannabigerol) have been found in studies to destroy cancer cells.

 

CBD oil to support cancer treatments

 

CBDhas been studied a great deal. It has been found in several studies to alleviate cancer-related symptoms, as well as to interfere with tumor growth (3,6,8). In general, CBD oil is very well tolerated and is suitable as a medicine or to support other treatment for children, adults and even animals.

Cannabinoids have been found to sensitize tumors, e.g. for chemotherapy. The body may develop drug resistance to the tumor, and cannabinoids apparently break down this tumor’s own resistance. (4)

 

Cancer treatment

 

Cancer is treated with many different methods. Chemotherapy, radiation treatments and numerous different drugs make it possible to treat even difficult cancers, but they are often followed by a wide variety of life-threatening side effects. The most common of these are probably loss of appetite, nausea and various mood challenges.

 

The selenium in Brazil nuts can

Like CBD, selenium is an antioxidant that promotes cell death. Selenium can be obtained e.g. Brazil nuts and it is in a highly absorbable form, e.g. also in Huminiqum products.

 

Natural treatment and possible prevention

 

A healthy, well-being body is the best and actually the only possible tool against cancer. Avoiding diseases is challenging, because today’s rhythm of life is extremely hectic, goal-oriented and stressful. Due to the impoverishment of the soil, we no longer get the nutrients we need from food, and the amount of pesticides and preservatives used in the cultivation of plants (including animal feed) is high. These affect the body’s resistance.

Certain vitamins have a negative effect on tumors. One of the most effective is selenium, which, like CBDis a mineral that promotes cell death. Selenium can be obtained e.g. Brazil nuts and it is in a highly absorbable form, e.g. also in Huminiqum capsules .

Selenium also has a positive effect on DNA damage, hormone production and challenges such as chronic inflammation and oxidative stress. There is only very little selenium in the Finnish diet, so the dose of selenium that protects against cancer is often missed. (9) The safe daily dose of selenium is 20-300 micrograms (µg) per day and it should be taken into account that selenium can cause poisoning when the dose is more than 4 milligrams, i.e. 4000 µg per day (10).

In addition, sulforaphane, especially found in bean sprouts and raw broccoli, is also good for cancer patients, as are foods rich in vitamin C such as oranges, rose hips and citrus fruits.

Good quality, versatile food contains plenty of different nutrients that the body needs, and because the body is wise, it knows how to heal itself and always strives to function optimally. In order to heal, the body needs time, rest and sufficient quality food with possible supplements. Clean drinking water is an important element, as is a sufficient amount of fresh outdoor air.

 

In summary

 

Cancer is often a challenging, life-stopping disease, at least momentarily. Treatment methods have increased and improved enormously in the past decades, but there is still no miracle pill for cancer treatment that would simply erase the symptoms without side effects. Researched drugs targeting the endocannabinoid system, making CBD oil a part of life and healthy optimized lifestyles are the cancer treatment of the future and support comprehensive well-being.

Sources

 

  1. All about cancer. https://www.kaikkisyovasta.fi. Referred to 20.7.2022
  2. Duodecim terveyskirjasto. Cancer. https://www.terveyskirjasto.fi/haku?q=syöpä. Referred to 20.7.2022
  3. Barbara Dariš B., Tancer Verboten M., Knez Z., Ferk P.. 2019. Cannabinoids in cancer treatment: Therapeutic potential and legislation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387667/. Referred to 20.7.2022
  4. Fraguas‐Sánchez A., Martín‐Sabroso C., ja Torres‐Suárez A.. 2018. Insights into the effects of the endocannabinoid system in cancer : a review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003657/. Referred to 20.7.2022
  5. Bifulco M. ja Di Marzo V.. 2002. Nature Medicine. Targeting the endocannabinoid system in cancer therapy: A call for further research. https://www.researchgate.net/profile/Maurizio-Bifulco/publication/11330003_Targeting_the_endocannabinoid_system_in_cancer_therapy_A_call_for_further_research/links/00b4951dc3c337696a000000/Targeting-the-endocannabinoid-system-in-cancer-therapy-A-call-for-further-research.pdf. Referred to 20.7.2022
  6. Seltzer E., Watters A., MacKenzie D., Jr. Granat L. and Zhang D.. 2020. Cannabidiol (CBD) as a Promising Anti-Cancer drug. https://pubmed.ncbi.nlm.nih.gov/?term=Zhang%20D%5BAuthor%5D. Referred to 20.7.2022.
  7. Velasco G., Hernandez-Tiera S., Davila D. ja Lorente M.. 2016. Science direct. The use of cannabinoids as anticancer agents. https://www.sciencedirect.com/science/article/pii/S0278584615001190.Viitattu 20.7.2022
  8. Moreno E., Cavic M., Krivokuca A., Casadó V., ja Canela E.. 2009. Frontiers. https://www.frontiersin.org/articles/10.3389/fphar.2019.00339/full. Referred to 20.7.2022
  9. K. Jaakkola. Terveyskirjat.fi. Erikoislääkäri Kaarlo Jaakkolan vastaanotolla: Selenium fights cancer. https://terveyskirjat.fi. Referred to 09.08.2022
  10. H. Jalonen. Selenium. https://www.bonusapteekki.fi/Apteekkarin-neuvot/Seleeni. Referred to 09.08.2022.
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